200064-13-7

Basic information

• Product Name: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE
• Synonyms: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE;3-BroMo-5-Morpholinopyridine
• CAS NO: 200064-13-7
• Molecular Formula: C₉H₁₁BrN₂O
• Molecular Weight: 243.103
• Mol File: 200064-13-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 87.9-89.5 °C
• Boiling Point: 354.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.499±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.45±0.22(Predicted)
• CAS DataBase Reference: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE(200064-13-7)
• EPA Substance Registry System: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE(200064-13-7)

Safety Data

• Hazardous Substances Data: 200064-13-7(Hazardous Substances Data)

Usage

General Description

4-(5-Bromopyridin-3-yl)morpholine is a chemical compound with the molecular formula C9H10BrN2O. It is a heterocyclic organic compound that contains a morpholine ring and a 5-bromopyridine moiety. 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. It has also been studied for its potential applications as a pesticide and as an ingredient in the production of agricultural chemicals. The compound has been found to exhibit a range of pharmacological activities, including antifungal and antimicrobial properties. As such, it is of interest for further research and development in the fields of medicinal and agricultural chemistry.

Upstream product

• 110-91-8 morpholine 
• 625-92-3 3,5-dibromopyridine 
• 1413439-93-6 C₉H₁₂N₂O₂ 
• 109-00-2 3-HYDROXYPYRIDINE 
• 1413439-82-3 C₉H₁₁BrF₃NO₃SSi 
• 1413439-81-2 C₁₂H₁₉BrN₂O₂Si 
• 37828-58-3 lithium morpholide 

Downstream Products

• 1312593-87-5 3-chloro-N-[6-methyl-3-[5-(4-morpholinyl)-3-pyridinyl]-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide 
• 1201644-33-8 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)-3-pyridinyl]morpholine 

Relevant articles and documents

A facile and efficient synthesis of 3-amino-5-bromopyridine derivatives using microwave irradiation

A facile and general synthetic strategy was developed to synthesize 3-amino-5-bromopyridine derivatives under microwave heating conditions. The strategy involved reacting 3,5-dibromopyridine with an excess of an aliphatic amine using microwave heating, without the need to use either metal-mediated, base-promoted or harsh long thermal reaction times. The microwave approach enabled the rapid synthesis of 3-amino-5-bromopyridine derivatives in multi-gram quantities from commercially available starting materials.

CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.