20009-28-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(Propargyloxy)naphthalene is used as a chemical intermediate for the synthesis of various pharmaceuticals, facilitating the creation of new drugs and enhancing the development of existing medications. Its unique structure allows for specific chemical reactions that are crucial in drug formulation.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Propargyloxy)naphthalene serves as a key intermediate in the production of pesticides and other agricultural chemicals, contributing to the development of more effective and targeted pest control solutions.
Used in Specialty Chemicals Production:
2-(Propargyloxy)naphthalene is utilized as a building block in the synthesis of specialty chemicals, which are often used in niche applications requiring specific chemical properties, such as in the fragrance, flavor, or dye industries.
Used in Research Laboratories:
2-(Propargyloxy)naphthalene is also employed in research settings, where it aids in the exploration of new chemical reactions and the development of innovative chemical processes, further expanding its utility in scientific discovery and technological advancement.

Upstream product

• 624-65-7 2-propynyl chloride 
• 135-19-3 β-naphthol 
• 6165-75-9 propargyl benzenesulfonate 
• 106-96-7 propargyl bromide 
• 574-19-6 1-(2-hydroxy-1-naphthyl)ethan-1-one 
• 52651-45-3 1-acetyl-2-propargyoxynaphthalene 

Downstream Products

• 13662-06-1 1-(naphthalen-2-yloxy)propan-2-one 
• 1147710-96-0 2-naphthyl 3-phenylselenylprop-2-yn-1-yl ether 
• 135-19-3 β-naphthol 
• 1426533-49-4 1-benzyl-4-(naphthalene-2-yloxymethyl)-1H-[1,2,3]triazole 
• 1449393-53-6 4-(naphthalene-2-yloxymethyl)-1-phenethyl-1H-[1,2,3]triazole 

Relevant academic research and scientific papers

Predicting self-assembly and structure in diluted aqueous solutions of modified mono- and bis-β-cyclodextrins that contain naphthoxy chromophore groups

The water diluted solution behaviour of mono- and bis-β-cyclodextrin (mono- and bis-CD) derivatives, whose appended groups and inter-CD linkers contain a naphthoxy chromophore moiety, has been studied using steady-state and time-resolved fluorescence techniques, circular dichroism and molecular modelling. Mono-CD derivatives form non-covalent dimeric tail-to-tail supramolecular structures via the mutual partial penetration, through their primary sides, of axially oriented naphthoxy appended groups and the self-inclusion of the naphthoxy moiety is rather improbable. Non-covalent dimer formation may compete with any guest complexation. Nevertheless, these assemblies can be broken up by decreasing medium polarity or when the appended group is captured by macrorings such as cucurbit[7]urils or native βCDs. Bis-CD derivatives, however, do not exhibit self-association processes which were observed in the mono-derivatives. This is because the presence of the bulky naphthoxy group in the spacer keeps the βCD cavities, which are capable of accommodating an external guest, away from each other. The dinaphthoxy group, in the bis-NβCD, was located in a quasi-parallel plane conformation between both CDs. This journal is

Design of novel anthracene-based fluorescence sensor for sensitive and selective determination of iron in real samples

A dipodal fluorescence (FL) system based on an anthracene platform was prepared by a general synthetic strategy. The water-miscible receptor was characterized by MALDI-MS, 1H NMR, 13C NMR, and FT-IR. In order to the illustration of photophysical properties of the synthesized sensor, the excitation–emission matrix (EEM) analysis and 3D-fluorescence measurements were performed. Ultraviolet-Visible (UV–vis) and FL spectroscopies were carried out to evaluate the FL performance of the sensor. Low concentrations of iron ions (Fe3+) could be determined by this sensitive and simple sensor. Due to the quenching effect of Fe3+, a limit of detection (LOD) of 0.314 μM was obtained in the linear range of 0.3–130 μM. This fluorescent sensor was applied for measuring ferric ions in environmental water and tablet samples, which was highly efficient. The proposed strategy could be applied to develop sensors for not only for Fe3+ but also for many various metal ions using a diversity of fluorophores and ionophores.

Tripodal synthetic receptors based on cyclotriphosphazene scaffold for highly selective and sensitive spectrofluorimetric determination of iron(III) in water samples

Two novel tripodal synthetic receptors based on cyclotriphosphazene scaffolds were prepared for spectrofluorimetric quantification of iron ions in environmental water samples. The receptors were designed by using the planar structure of cyclotriphosphazene which were modified by metal ion detecting naphtalene or anthracene-triazole groups above the plane and water solubility interacting triethylene glycol monomethyl ether (TEGME) groups below. All compounds were characterized by standard spectroscopic techniques such as 1H, 13C, 31P NMR and mass spectrometry (MALDI-TOF). The new developed methods based selective and sensitive complexation of CBTSRs with iron prior to spectrofluorimetric determination without any preconcentration processes. The experimental conditions such as pH, buffer and buffer concentration, initial CBTSRs concentration and time before measurement were optimized for selective complexation, which provided submicromolar spectrofluorimetric determination of iron under optimized conditions. The obtained results demonstrated that CBTSRs led to develop sensitive (LODs, 0.54 and 0.44 μM), selective and time-saving spectrofluorimetric methods for quantification of iron ions in environmental water samples under the optimized conditions (pH, 7.0; initial CBTSRs concentration, 10 μM and 5 μM; solvent, aqueous ethanol, (3:1 v/v and 9:1 v/v); buffer and buffer concentration, 0.1 M Britton-Robinson buffer; time before measurement, 20 and 25 s).

Cu(I) catalyzed coumarin-1,2,3-triazole hybrids: Click chemistry

A series of novel coumarin-1,2,3-triazole derivatives were synthesized in good yield via click chemistry using Cu(I) catalyzed intermolecular Huisgen [3+2] cycloaddition reaction. All the synthesized compounds were characterized spectroscopically. This piece of work could be helpful to develop biologically relevant coumarin analogs.

Application of artificially synthesized palladium nano-enzyme to catalysis of compound containing phenolic hydroxyl group connection

The invention provides application of an artificially synthesized palladium nano-enzyme to catalysis of a compound containing phenolic hydroxyl connection. The palladium nano-enzyme is used for catalyzing breakage of a carbon-oxygen bond of propargyloxy connected with an aromatic functional group containing at least one benzene ring; the aromatic functional group containing at least one benzene ring comprises but is not limited to fluorescein, the benzene ring, a pyridine ring, biphenyl, naphthalene, anthracene, coumarin or camptothecin, and the aromatic functional group containing at least one benzene ring can be connected with oxygen or oxygen-carbonyl oxygen or oxygen-carbonyl oxygen-oxygen. By constructing different artificially synthesized palladium nano-enzymes, the carbon-oxygen bond breakage of various molecules can be realized, and the palladium nano-enzymes can be applied to cell imaging and cancer treatment.

A novel series of substituted 1,2,3-triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation

An alarming increase in global death toll resulting from cancer incidents, particularly due to multidrug resistance and reduced efficacy as a consequence of target mutations, has compelled us to look for novel anticancer agents. Cancer stem cells (CSCs),

Preparation method and application of propyne aryl ether compound

The invention particularly relates to a method for preparing propyne aryl ether compounds from aryl phenol, halogenated propyne and derivatives of the halogenated propyne, and belongs to the technical field of preparation of the propyne aryl ether compoun

TiO2/Cu2O nanoparticle-catalyzed direct C(sp)-P bond formation: Via aerobic oxidative coupling in air and visible light

The synthesis of organophosphorus compounds is one of the important goals in organic chemistry. Among these compounds, alkynylphosphonates are significantly utilized as the main precursors for the synthesis of biologically active molecules in medicinal chemistry and have attracted extensive interest in the past few decades. Although few efforts have been made towards the direct and atom-economical synthesis of alkynylphosphonates, efforts towards the utilization of visible light as a green and renewable energy source have not been made to date. Here, we have promoted a strategy to construct a type of nano metal oxide composite photocatalyst (Cu2O decorated on TiO2) for the synthesis of alkynylphosphonates via direct C-P bond formation between terminal alkyne and H-phosphonate under visible light irradiation. In this p-n heterojunction photocatalyst, Cu2O acted as a visible-light absorber; moreover, the CB (conduction band) of TiO2 was favorable for accepting a photogenerated electron, and the generated electron hole (e-/h+) pair could initiate the reaction. The present study can provide a new way for the synthesis of this important class of phosphorus organic compounds.

Synthesis and neuroprotective effects of novel chalcone-triazole hybrids

The development of novel neuroprotective agents is urgently needed for the treatment of neurodegenerative diseases, affecting aging individuals worldwide. In this study, a new set of chalcone-triazole hybrids (6a-g) was synthesized and evaluated for their

Iron(III)-Catalyzed Domino Claisen Rearrangement/Regio- And Chemoselective Aerobic Dehydrogenative Cyclization of β-Naphthyl-Substituted-Allenylmethyl Ether

An FeCl3-catalyzed allenic Claisen rearrangement/regio- and chemoselective aerobic dehydrogenative cyclization domino reaction is developed, providing a wide range of 2-aryl/alkyl, 3-(substituted-vinyl)naphtho[2,1-b]furans in high yields at 95-130 °C in a