20009-28-3Relevant articles and documents
Predicting self-assembly and structure in diluted aqueous solutions of modified mono- and bis-β-cyclodextrins that contain naphthoxy chromophore groups
Carmona, Thais,Martina, Katia,Rinaldi, Laura,Boffa, Luisa,Cravotto, Giancarlo,Mendicuti, Francisco
, p. 1714 - 1724 (2015)
The water diluted solution behaviour of mono- and bis-β-cyclodextrin (mono- and bis-CD) derivatives, whose appended groups and inter-CD linkers contain a naphthoxy chromophore moiety, has been studied using steady-state and time-resolved fluorescence techniques, circular dichroism and molecular modelling. Mono-CD derivatives form non-covalent dimeric tail-to-tail supramolecular structures via the mutual partial penetration, through their primary sides, of axially oriented naphthoxy appended groups and the self-inclusion of the naphthoxy moiety is rather improbable. Non-covalent dimer formation may compete with any guest complexation. Nevertheless, these assemblies can be broken up by decreasing medium polarity or when the appended group is captured by macrorings such as cucurbit[7]urils or native βCDs. Bis-CD derivatives, however, do not exhibit self-association processes which were observed in the mono-derivatives. This is because the presence of the bulky naphthoxy group in the spacer keeps the βCD cavities, which are capable of accommodating an external guest, away from each other. The dinaphthoxy group, in the bis-NβCD, was located in a quasi-parallel plane conformation between both CDs. This journal is
Tripodal synthetic receptors based on cyclotriphosphazene scaffold for highly selective and sensitive spectrofluorimetric determination of iron(III) in water samples
Tümay, Süreyya O?uz,Ye?ilot, Serkan
, p. 156 - 167 (2019)
Two novel tripodal synthetic receptors based on cyclotriphosphazene scaffolds were prepared for spectrofluorimetric quantification of iron ions in environmental water samples. The receptors were designed by using the planar structure of cyclotriphosphazene which were modified by metal ion detecting naphtalene or anthracene-triazole groups above the plane and water solubility interacting triethylene glycol monomethyl ether (TEGME) groups below. All compounds were characterized by standard spectroscopic techniques such as 1H, 13C, 31P NMR and mass spectrometry (MALDI-TOF). The new developed methods based selective and sensitive complexation of CBTSRs with iron prior to spectrofluorimetric determination without any preconcentration processes. The experimental conditions such as pH, buffer and buffer concentration, initial CBTSRs concentration and time before measurement were optimized for selective complexation, which provided submicromolar spectrofluorimetric determination of iron under optimized conditions. The obtained results demonstrated that CBTSRs led to develop sensitive (LODs, 0.54 and 0.44 μM), selective and time-saving spectrofluorimetric methods for quantification of iron ions in environmental water samples under the optimized conditions (pH, 7.0; initial CBTSRs concentration, 10 μM and 5 μM; solvent, aqueous ethanol, (3:1 v/v and 9:1 v/v); buffer and buffer concentration, 0.1 M Britton-Robinson buffer; time before measurement, 20 and 25 s).
Application of artificially synthesized palladium nano-enzyme to catalysis of compound containing phenolic hydroxyl group connection
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Paragraph 0038-0039; 0042-0043; 0048-0049, (2021/09/04)
The invention provides application of an artificially synthesized palladium nano-enzyme to catalysis of a compound containing phenolic hydroxyl connection. The palladium nano-enzyme is used for catalyzing breakage of a carbon-oxygen bond of propargyloxy connected with an aromatic functional group containing at least one benzene ring; the aromatic functional group containing at least one benzene ring comprises but is not limited to fluorescein, the benzene ring, a pyridine ring, biphenyl, naphthalene, anthracene, coumarin or camptothecin, and the aromatic functional group containing at least one benzene ring can be connected with oxygen or oxygen-carbonyl oxygen or oxygen-carbonyl oxygen-oxygen. By constructing different artificially synthesized palladium nano-enzymes, the carbon-oxygen bond breakage of various molecules can be realized, and the palladium nano-enzymes can be applied to cell imaging and cancer treatment.
A novel series of substituted 1,2,3-triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation
Padhariya, Komal N.,Athavale, Maithili,Srivastava, Sangeeta,Kharkar, Prashant S.
, p. 68 - 85 (2020/08/14)
An alarming increase in global death toll resulting from cancer incidents, particularly due to multidrug resistance and reduced efficacy as a consequence of target mutations, has compelled us to look for novel anticancer agents. Cancer stem cells (CSCs),
