20011-11-4

Basic information

• Product Name: Piperazine, 1-(3-chlorophenyl)-4-methyl-
• Synonyms: Piperazine, 1-(3-chlorophenyl)-4-methyl-;1-(3-Chlorophenyl)-4-methylpiperazine
• CAS NO: 20011-11-4
• Molecular Formula: C₁₁H₁₅ClN₂
• Molecular Weight: 211
• Mol File: 20011-11-4.mol

Chemical Properties

• Boiling Point: 315℃
• Flash Point: 144℃
• Appearance: /
• Density: 1.140
• PKA: 7.67±0.42(Predicted)
• CAS DataBase Reference: Piperazine, 1-(3-chlorophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3-chlorophenyl)-4-methyl-(20011-11-4)
• EPA Substance Registry System: Piperazine, 1-(3-chlorophenyl)-4-methyl-(20011-11-4)

Safety Data

• Hazardous Substances Data: 20011-11-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine, 1-(3-chlorophenyl)-4-methylis used as an active pharmaceutical ingredient for the development of antipsychotic and antihistaminic medications. Its chemical structure contributes to its biological activity and therapeutic effects, making it a valuable compound in the treatment of mental health disorders.
Used in Mental Health Treatment:
In the mental health treatment industry, Piperazine, 1-(3-chlorophenyl)-4-methylis used as a therapeutic agent for the management of conditions such as schizophrenia and bipolar disorder. Its pharmacological properties enable it to modulate neurotransmitter levels and alleviate symptoms associated with these disorders.
Used in Neurological Condition Management:
Piperazine, 1-(3-chlorophenyl)-4-methylis also utilized in the neurological condition management industry as a potential treatment for various neurological disorders. Its ability to cross the blood-brain barrier and interact with specific receptors makes it a promising candidate for the development of medications targeting neurological conditions.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 541-73-1 1,3-Dichlorobenzene 
• 50-00-0 formaldehyd 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 74-83-9 methyl bromide 

Downstream Products

• 103863-85-0 (3-hexylmercapto-phenyl)-[3-(4-methyl-piperazino)-propyl]-phenyl-amine 

Relevant articles and documents

N-heterocyclic carbene-Pd(II)-2-methyl-4,5-dihydrooxazole complex-catalyzed highly chemoselective mono-amination of dichlorobenzenes

The palladium-catalyzed chemoselective mono-amination of dichlorobenzenes was reported in this paper. Under the suitable conditions, all reactions involving the three isomers of dichlorobenzenes with various secondary and primary amines in the presence of

Nickel-catalysed synthesis of 3-chloroanilines and chloro aminopyridines via cross-coupling reactions of aryl and heteroaryl dichlorides with amines

Selective monoamination of aryl and heteroaryl dichlorides has been carried out using a catalyst combination of Ni(0) associated to 2,2′-bipyridine. The synthesis of novel 3-chloroanilines and chloro aminopyridines in good to excellent yields is allowed u

Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP)

DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for α4β2 receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (Ki = 90 nM) and 14b (Ki = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.

Nickel-catalysed couplings of aryl chlorides with secondary amines and piperazines

The reaction of aryl chlorides with secondary amines or piperazines in the presence of an in situ generated liganded nickel catalyst gives arylamines in good yields. Our process provides a mild, convenient and cheap method of arylamination starting from readily available substrates.

Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3- chlorophenyl)piperazines for 5-HT(1A) receptor site

The effect of the hydrocarbon chain of the model 4-substituted 1-(3- chlorophenyl)piperazines 12-31 on their affinity for 5-HT(1A) receptor sites was investigated. It was found that elongation of the 4-n-alkyl chain strongly increases the 5-HT(1A) affinit