20011-21-6Relevant articles and documents
Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands
Szczepańska, Katarzyna,Karcz, Tadeusz,Siwek,Kuder, Kamil J.,Latacz, Gniewomir,Bednarski,Szafarz, Ma?gorzata,Hagenow, Stefanie,Lubelska, Annamaria,Olejarz-Maciej, Agnieszka,Sobolewski, Micha?,Mika,Kotańska, Magdalena,Stark, Holger,Kie?-Kononowicz, Katarzyna
, (2019)
A novel series of 4-pyridylpiperazine derivatives with varying alkyl linker length and eastern part substituents proved to be potent histamine H3 receptor (hH3R) ligands in the nanomolar concentration range. While paying attention to
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands
Kuder, Kamil J.,?a?ewska, Dorota,Kaleta, Maria,Latacz, Gniewomir,Kottke, Tim,Olejarz, Agnieszka,Karcz, Tadeusz,Fruziński, Andrzej,Szczepańska, Katarzyna,Karolak-Wojciechowska, Janina,Stark, Holger,Kie?-Kononowicz, Katarzyna
supporting information, p. 2701 - 2712 (2017/04/18)
As a continuation of our search for novel histamine H3 receptor ligands a series of twenty new tert-amyl phenoxyalkylamine derivatives (2–21) was synthesized. Compounds of four to eight carbon atoms spacer alkyl chain were evaluated on their bi