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200123-51-9

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200123-51-9 Usage

General Description

H-DL-LEU-OBZL P-TOSYLATE is a chemical compound with the molecular formula C27H35N5O8S, consisting of the amino acid leucine bound to a tosylate group, which is a derivative of toluenesulfonic acid. H-DL-LEU-OBZL P-TOSYLATE is commonly used in pharmaceutical research as a reversible inhibitor of aminopeptidases. It works by binding to the active site of these enzymes, effectively blocking their function and inhibiting the hydrolysis of peptides. H-DL-LEU-OBZL P-TOSYLATE has shown potential as a tool for investigating the role of aminopeptidases in various biological pathways and as a potential target for therapeutic intervention in diseases such as cancer and cardiovascular disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 200123-51-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,1,2 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 200123-51:
(8*2)+(7*0)+(6*0)+(5*1)+(4*2)+(3*3)+(2*5)+(1*1)=49
49 % 10 = 9
So 200123-51-9 is a valid CAS Registry Number.

200123-51-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name benzyl 2-amino-4-methylpentanoate,4-methylbenzenesulfonic acid

1.2 Other means of identification

Product number -
Other names H-DL-Leu-OBzl TosOH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:200123-51-9 SDS

200123-51-9Relevant articles and documents

One-step preparation of enantiopure l- or d-amino acid benzyl esters avoiding the use of banned solvents

Bolchi, Cristiano,Bavo, Francesco,Pallavicini, Marco

, p. 965 - 974 (2017/04/11)

The enantiomers of amino acid benzyl esters are very important synthetic intermediates. Many of them are currently prepared by treatment with benzyl alcohol and p-toluenesulfonic acid in refluxing benzene or carbon tetrachloride, to azeotropically remove water, and then precipitated as tosylate salt by adding diethyl ether. Here, we report a very efficient preparation of eight l- or d-amino acid benzyl esters (Ala, Phe, Tyr, Phg, Val, Leu, Lys, Ser), in which these highly hazardous solvents are dismissed using cyclohexane as a water azeotroping solvent and ethyl acetate to precipitate the tosylate salt. With some work-up modifications and lower yield, the procedure can be applied also to methionine. Chiral HPLC analysis shows that all the benzyl esters, including the highly racemizable ones such as those of phenylglycine, tyrosine and methionine, are formed enantiomerically pure under these new reaction conditions thus validating the solvents replacement. Contrariwise, toluene cannot be used in place of benzene or carbon tetrachloride because leading to partially or totally racemized amino acid benzyl esters depending on the polar effect of the amino acid α-side chain as expressed by Taft’s substituent constant (σ*).

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