200191-60-2

Upstream product

• 65-85-0 benzoic acid 
• 171667-67-7 (3S,4R,5R,6S)-4,5-Bis-benzyloxy-thiepane-3,6-diol 
• 157363-85-4 1,2:5,6-Dianhydro-3,4-di-O-benzyl-D-mannitol 

Downstream Products

• 200191-81-7 (3S,4R,5S,6S)-4,5-Bis-benzyloxy-6-hydroxymethyl-1,1-dioxo-hexahydro-1λ⁶-thiopyran-3-ol 
• 200191-80-6 (1S,3S,4R,5S,6S)-4,5-Bis-benzyloxy-6-hydroxymethyl-1-oxo-hexahydro-1λ⁴-thiopyran-3-ol 
• 200191-55-5 (3S,4R,5S,6S)-4,5-Bis-benzyloxy-6-hydroxymethyl-tetrahydro-thiopyran-3-ol 

Relevant academic research and scientific papers

Synthesis of thiosugars as weak inhibitors of glycosidases

A series of enantiomerically pure thiosugars (1,6-dideoxy-1,6-thio-D- mannitol or L-iditol, 1,5-dideoxy-1,5-thio-L-gulitol or D-glucitol and 2,5- dideoxy-2,5-thio-L-iditol or D-mannitol, and their corresponding sulfoxide or sulfone) was synthesized via thiocyclization of C2-symmetric bis-epoxides, and subsequently followed by ring isomerization in few cases. These compounds have been evaluated as inhibitors of several glycosidases (α- and β-D- glucosidases, α-D-mannosidase and α-L-fucosidase).

THIOSUGARS FROM D-MANNITOL

Enantiomerically pure thiosugars, with a thiepan, tetrahydrothiopyran or tetrahydrothiophene backbone, have been synthesized by thio-heterocyclization of enantiopure C2-symmetric bis-epoxides and possibly ring contraction. - Key words: Thiosuga