200214-17-1

Upstream product

• 50-00-0 formaldehyd 
• 35553-92-5 ETHYL 3-METHOXYPHENYLACETATE 
• 92848-09-4 ethyl 3-oxo-2-(m-methoxyphenyl)propanoate 

Downstream Products

• 155440-93-0 2-(3-methoxyphenyl)-1,3-propanediol 
• 79539-58-5 5-(4-Methoxy-phenyl)-2-phenyl-[1,3]dioxane 
• 79539-62-1 4-[5-(4-Methoxy-phenyl)-[1,3]dioxan-2-yl]-pyridine 
• 79539-60-9 2-[5-(4-Methoxy-phenyl)-[1,3]dioxan-2-yl]-pyridine 
• 79539-59-6 2,5-Bis-(4-methoxy-phenyl)-[1,3]dioxane 
• 16864-47-4 (R,S)-3-hydroxy-2-(3-methoxyphenyl)-propionic acid 

Relevant academic research and scientific papers

1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer

A compound of Formula (I): or a pharmaceutically acceptable salt thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R1 can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, or 3,3-difluoroazetidin-1-yl; R2 can be hydrogen or fluoro; R3 can be hydrogen or methoxy; and R4 can be methoxy, ethoxy, or methoxymethyl; provided that when R1 is hydrogen, methoxy or trifluoromethoxy, then R3 is not hydrogen, and/or R4 is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.