20025-59-6

Basic information

• Product Name: 3-(BIPHENYL-4-SULFONYL)-PROPIONIC ACID
• Synonyms: 3-(BIPHENYL-4-SULFONYL)-PROPIONIC ACID
• CAS NO: 20025-59-6
• Molecular Formula: C₁₅H₁₄O₄S
• Molecular Weight: 290.33
• Mol File: 20025-59-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(BIPHENYL-4-SULFONYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BIPHENYL-4-SULFONYL)-PROPIONIC ACID(20025-59-6)
• EPA Substance Registry System: 3-(BIPHENYL-4-SULFONYL)-PROPIONIC ACID(20025-59-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 20025-59-6(Hazardous Substances Data)

Upstream product

• 1623-93-4 4-diphenylsulfonyl chloride 
• 590-92-1 3-Bromopropionic acid 
• 19813-90-2 4-biphenylthiol 

Downstream Products

• 392329-02-1 3-[(4-Biphenyl)sulfonyl]-N-methyl-N-[1-(4-pyridyl)-4-piperidyl]propanamide 

Relevant articles and documents

Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.

Fenbufen, a new anti inflammatory analgesic: synthesis and structure activity relationships of analogs

100 analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti inflammatory tests and the 2 phenyl 1,4 benzoquinone writhing and inflamed paw pressure analgesic tests. Only 3 retained the same full spectrum of activity as fenbufen: dl 4 (4 biphenylyl) 4 hydroxybutyric acid, dl 4 (4 biphenylyl) 1,4 butanediol, and 4 biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the 5 tests. In addition, dose response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all 5 tests. Two related compounds were generally similar.