200259-33-2Relevant academic research and scientific papers
On an electrode modified by a supramolecular ruthenium mixed valence (RuII/RuIIII) diphosphine-porphyrin assembly
Dinelli, Luis R.,Von Poelhsitz, Gustavo,Castellano, Eduardo E.,Ellena, Javier,Galembeck, Segio E.,Batista, Alzir A.
, p. 4692 - 4700 (2009)
Three novel polymetallic ruthenium (III) mesotetra(4-pyridyl)porphyrins containing peripheral "RuCI3(dppb)" moieties have been prepared and characterized. The X-ray structure of the tetraruthenated {NiTPyP[RuCI3(dppb)]4} p
Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis
Colina-Vegas, Legna,Dutra, Jocely Lucena,Villarreal, Wilmer,de A. Neto, Jo?o Honorato,Cominetti, Marcia Regina,Pavan, Fernando,Navarro, Maribel,Batista, Alzir A.
, p. 135 - 145 (2016/11/12)
Three ruthenium complexes [RuCl(CTZ)(bipy)(P-P)]PF6 [P-P?=?1,2-bis(diphenylphosphino)ethane (dppe-1), 1,4-bis(diphenylphosphino)butane (dppb-2) and 1,1′-bis(diphenylphosphino)ferrocene (dppf-3), bipy?=?2,2′-bipiridine and clotrimazole (CTZ) 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole] were synthesized. These complexes were characterized by a combination of elemental analysis, molar conductivity, infrared and UV–vis spectroscopy, 1H, 13C{1H} and 31P{1H} nuclear magnetic resonance techniques, cyclic voltammetry and mass spectroscopy. Bovine serum albumin binding constants, which were in the range of 1.30–36.00?×?104?M??1, and thermodynamic parameters suggest spontaneous interactions with this protein by electrostatic forces due to the positive charge of the complexes. DNA interactions studied by spectroscopic titration, viscosity measurements, gel electrophoresis, circular dichroism, ethidium bromide displacement and reactions with guanosine and guanosine monophosphate indicated the DNA binding affinity primarily through non-covalent interactions. All complexes 1–3 were tested against the human carcinoma cell lines MCF-7 (breast), A549 (lung) and DU-145 (prostate) presenting promising IC50 values, between 0.50 and 14.00?μM, in some cases lower than the IC50 for the reference drug (cisplatin). The antimicrobial activity assays of the complexes provided evidence that they are potential agents against mycobacterial infections, specifically against Mycobacterium tuberculosis H37Rv.
The mer-[RuCl3(dppb)(H2O)] complex: A versatile tool for synthesis of RuII compounds
Barbosa, Marilia I.F.,Santos, Edjane R. Dos,Graminha, Angelica E.,Bogado, André L.,Teixeira, Leticia R.,Beraldo, Heloisa,Trevisan, Maria Teresa S.,Ellena, Javier,Castellano, Eduardo E.,Rodrigues, Bernardo L.,De Araujo, Márcio P.,Batista, Alzir A.
, p. 41 - 46 (2011/02/27)
The complex mer-[RuCl3(dppb)(H2O)] [dppb = 1,4-bis(diphenylphosphino)butane] was used as a precursor in the synthesis of the complexes tc-[RuCl2(CO)2(dppb)], ct-[RuCl 2(CO)2(dppb)], cis-[Ru
Photochemical isomerization of trans- to cis-[RuCl2(dppb) (4,4′-X2-2,2′-bipy)] (X = -H, -NO2, -Me, -COOH, -SMe, -O=SMe, -Cl, -OMe) complexes
Santiago, Marcelo O.,Donicci Filho, Claudio L.,Moreira, Icaro de S.,Carlos, Rose Maria,Queiroz, Salete L.,Batista, Alzir A.
, p. 3205 - 3211 (2008/10/08)
A series of [RuCl2(dppb)(4,4′-X2-2,2′ -bipy)] complexes was synthesized from [RuCl2(dppb)(PPh3) and 4,4′-X2-2,2′-bipy [dppb=1,4-bis(diphenylphosphino)butane and 4,4′-X2-2,2′ -bipy=2,2′-bipyridine (bipy), 4,4′-dimethoxy-2,2′-bipyridine (MeO-bipy), 4,4′-dimethyl-2,2′-bipyridine (Me-bipy), 4,4′-dicarboxy-2,2′-bipyridine (COOH-bipy), 4,4′ -dithiomethyl-2,2′-bipyridine (MeS-bipy), 4,4′-dichloro-2,2′ -bipyridine (Cl-bipy), 4,4′-dinitro-2,2′-bipyridine (NO 2-bipy), and 4,4′-dithiomethylsulphoxide-2, 2′-bipyridine (MeS=O-bipy)]. The complexes were characterized by elemental analysis, cyclic voltammetry and differential pulse voltammetry, and by UV-Vis and 31P{1H}NMR spectroscopies. The pK a of the ligands were determined. The trans-[RuCl 2(dppb)(4,4′-X2-2,2′-bipy) complexes were photoisomerized under white light and the isomerization rate constants from trans to cis isomers were consistent with first order reactions and were correlated with the pKa of the ligands and with the E1/2 of the complexes. The suggested mechanism of isomerization reactions is consistent with an intramolecular twist process.
The reactivity of five-coordinate Ru(II) (1,4-bis(diphenylphosphino)butane) complexes with the N-donor ligands: Ammonia, pyridine, 4-substituted pyridines, 2,2′-bipyridine, bis(o-pyridyl)amine, 1,10-phenanthroline, 4,7-diphenylphenanthroline and ethylenediamine
Queiroz, Salete L.,Batista, Alzir A.,Oliva, Glaucius,Gambardella, Maria Teresa do P.,Santos, Regina H.A.,MacFarlane, Kenneth S.,Rettig, Steven J.,James, Brian R.
, p. 209 - 221 (2008/10/08)
A series of Ru(II) (1,4-bis(diphenylphosphino)butane)(L)2complexes was synthesized from [RuCl2(dppb)]2(μ-dppb) or RuCl2(dppb)-(PPh3); dppb=Ph2P(CH2)4PPh2, L=NH3, pyridine (py), 4-aminopyridine (4-NH2py), 4-cyanopyridine (4-CNpy), 4-dimethylaminopyridine (4-Me2Npy), 4-methylpyridine (4-Mepy), 4-phenylpyridine (4-Phpy), 4-vinylpyridine (4-Vpy) and N-methylimidazole (MeIm), and L2=2,2′-bipyridine (bipy), bis(o-pyridyl)amine (bpa), 1,10-phenanthroline (phen),4,7-diphenylphenanthroline (or bathophenanthroline, batho) and ethylenediamine (en). The complexes were characterized by elemental analysis, cyclic voltammetry, UV-Vis, NMR and IR spectroscopies. The structures of trans-RuCl2(dppb)(py)2 (3), cis-RuCl2(dppb)(bipy) (4) and cis-RuCl2(dppb)(phen) (5) were established by X-ray crystallographic analyses. Crystals of trans-3, cis-4 · CH2Cl2 and cis-5 · solvate are all monoclinic, space group P21/c, with Z=4; a=12.946(2), b=14.204(3), c=18.439(4) A, β=90.08(2)° for trans-3; a=10.694(6), b=18.485(6), c=18.632(7) A, β= 90.26(3)° for cis-4 · CH2Cl2; a=17.094(1), b=9.923(2), c=21.905(2) A, β=98.883(6)° for cis-5 · solvate. The structures were solved by the heavy atom Patterson method and were refined by full-matrix least-squares procedures to R=0.069, 0.071 and 0.036 (Rw=0.069, 0.076 and 0.039) for 1957, 4165 and 4824 reflections with I ≥ 3σ(I), respectively.
