200283-13-2Relevant academic research and scientific papers
Synthesis of two maleimide derivatives of cis-configurated platinum (II) complexes for the preparation of chemoimmunoconjugates
Schuette, Mark Thomas,Schumacher, Peter,Unger, Clemens,Muelhaupt, Rolf,Kratz, Felix
, p. 133 - 136 (1998)
By attaching maleimide groups to anticancer drugs, derivatives are obtained which bind selectively to thiolated carrier proteins. Two maleimide ester derivatives of platinum(II) complexes which consist of an active cis-configurated platinum(II) moiety and a maleimide group capable of binding to thiolated carriers were prepared, i.e. N-(O-(3-maleimidobenzoyl)-2-hydroxyethyl)-1,2-diaminoethanedichloroplatinum(II) (7) and N-(O-(2-(4-maleimidophenyl)acetyl)-2-hydroxyethyl)-1,2- diaminoethanedichloroplatinum(II) (8). 7 and 8 were characterized through 1H and 13C NMR spectroscopy, IR spectroscopy, elemental analysis and mass spectrometry (FAB).
