2003-05-6

Basic information

• Product Name: 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide
• Synonyms: 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide;acetamide, 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]-;2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]ethanamide
• CAS NO: 2003-05-6
• Molecular Formula: C₉H₆BrClF₃NO
• Molecular Weight: 316.5022496
• Mol File: 2003-05-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide(2003-05-6)
• EPA Substance Registry System: 2-bromo-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide(2003-05-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2003-05-6(Hazardous Substances Data)

Upstream product

• 557-68-6 iodobromomethane 
• 50528-86-4 2-chloro-5-(trifluoromethyl)phenyl isocyanate 

Relevant articles and documents

Addition of lithium carbenoids to isocyanates: A direct access to synthetically useful N-substituted 2-haloacetamides

The addition of lithium carbenoids to isocyanates provides a versatile access to N-substituted 2-haloacetamides: the reaction tolerates the presence of variously functionalized substituents on the nitrogen atom, including sterically demanding ones and reactive halogens. No erosion of the enantiopurity was observed in the case of optically active isocyanates. One of the substrates prepared has been employed in Charette's type chemoselective addition of a Grignard reagent to access an α-chloroketone.