200343-49-3Relevant academic research and scientific papers
Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: Novel inhibitors of COX-2
Lazer, Edward S.,Sorcek, Ronald,Cywin, Charles L.,Thome, Diane,Possanza, Genus J.,Graham, Anne G.,Churchill, Laurie
, p. 1181 - 1186 (1998)
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase- 2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
