Bioorganic and Medicinal Chemistry Letters p. 1181 - 1186 (1998)
Update date:2022-08-05
Topics:
Lazer, Edward S.
Sorcek, Ronald
Cywin, Charles L.
Thome, Diane
Possanza, Genus J.
Graham, Anne G.
Churchill, Laurie
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase- 2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
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