Bioorganic and Medicinal Chemistry Letters p. 1181 - 1186 (1998)
Update date:2022-08-05
Topics:
Lazer, Edward S.
Sorcek, Ronald
Cywin, Charles L.
Thome, Diane
Possanza, Genus J.
Graham, Anne G.
Churchill, Laurie
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase- 2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
View MoreContact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
HANGZHOU TOYOND BIOTECH CO., LTD
Contact:+86-571-86965177
Address:No. 189, Fengqi East Road, Hangzhou, China
Shanghai Hanhong Scientific Co.,Ltd.
website:http://www.chemvia.com
Contact:+86-21-64541543,54280654,13918533501
Address:Jiachuan Road 245
Doi:10.1021/ja01342a046
(1932)Doi:10.3987/COM-06-10726
(2006)Doi:10.1021/acs.jmedchem.8b01060
(2018)Doi:10.1021/jm980519u
(1999)Doi:10.1039/c8sm00773j
(2018)Doi:10.1081/NCN-120003176
(2002)
