Bioorganic and Medicinal Chemistry Letters p. 1181 - 1186 (1998)
Update date:2022-08-05
Topics:
Lazer, Edward S.
Sorcek, Ronald
Cywin, Charles L.
Thome, Diane
Possanza, Genus J.
Graham, Anne G.
Churchill, Laurie
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase- 2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
View MoreSpringchem New Material Technology Co.,Limited
website:http://www.spring-chem.com
Contact:86-21-62885108
Address:602B, Building 1, No. 641, Tianshan Road
Weifang Ocean Trading Co., Ltd.
Contact:+86-536-2081155
Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China
Chengdu CSH Pharmaceutical Co.,ltd
Contact:+86-(28)-85321971
Address:Block B,New Hope Int. Tian Fu New District, Chengdu, Sichuan, China
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD
Contact:+86-570-6040289
Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Anhui Redstar Pharmaceutical Corp., Ltd
Contact:+86-563-5120837
Address:Jingxian Industrial Development Zone, Anhui , China
Doi:10.1021/ja01342a046
(1932)Doi:10.3987/COM-06-10726
(2006)Doi:10.1021/acs.jmedchem.8b01060
(2018)Doi:10.1021/jm980519u
(1999)Doi:10.1039/c8sm00773j
(2018)Doi:10.1081/NCN-120003176
(2002)
