200344-97-4

Upstream product

• 97188-23-3 3-ethyl-1-phenylsulfonylpyrrole 
• 200344-99-6 4-ethyl-3-(4-nitrobenzoyl)-1H-pyrrole 
• 122-04-3 4-nitro-benzoyl chloride 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 200344-69-0 4-[3-Ethyl-4-(4-nitro-benzoyl)-pyrrol-1-yl]-butyric acid ethyl ester 

Downstream Products

• 199993-16-3 4-[3-(4-{[Bis-(4-isobutyl-phenyl)-methyl]-amino}-benzoyl)-4-ethyl-pyrrol-1-yl]-butyric acid ethyl ester 

Relevant academic research and scientific papers

Pyrrole butyric acid derivatives as inhibitors of steroid 5α- reductase

A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.