200399-55-9Relevant academic research and scientific papers
Design of a novel cognitive enhancer (8S, 10aS)-8-carbamoyl-1,2,3,6,7,8,9,10a-octahydro-5H,10H-pyrrolo[1,2a][1,4 ]diazocin-5,10-dione
Mazurov, Anatoly A.,Andronati, Sergei A.,Korotenko, Tamara I.,Sokolenko, Nikolai I.,Dyadenko, Alexei I.,Shapiro, Yuri E.,Gorbatyuk, Vitalii Ya.,Voronina, Tatyana A.
, p. 2595 - 2600 (1996)
A new cognitive enhancer (8S, 10aS)-8-carbamoyl-1,2,3,6,7,8,9,10a-octahydro-5H,10H-pyrrolo[1,2-a][1, 4]diazocin-5,10-dione (3) has been designed based on the approach consisting of two steps: 1) 'obligatory' replacement of histidine with glutamine in TRH; 2) the application of conformational constraints for putative bioactive conformation of [Gln2]-TRH. 3 reversed on 100% electroconvulsive shock-induced amnesia at doses of 0.1 and 1.0 mg/kg and on 83% scopolamine-induced amnesia at a dose of 1 mg/kg, using passive avoidance test.
TRH mimetics: Differentiation of antiamnesic potency from antidepressant effect
Mazurov, Anatoly A.,Andronati, Sergei A.,Korotenko, Tamara I.,Sokolenko, Nikolai I.,Dyadenko, Alexei I.,Shapiro, Yury E.,Gorbatyuk, Vitalii Ya.,Voronina, Tatyana A.
, p. 2029 - 2040 (2007/10/03)
For the purpose of rational modification of the TRH molecule, we were pursuing an approach that consists of two steps: (1) 'obligatory' replacement of histidine with glutamine in TRH and (2) the application of conformational constraints for putative bioac
