200400-76-6

Usage

Uses

Ethyl 2-(4'-hydroxyphenyl)-1,3-oxazole-4-carboxylate is used as a chemical intermediate in the synthesis of various pharmaceutical compounds. Its unique structure, which includes the hydroxyphenyl group and the oxazole ring, makes it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Pharmaceutical Industry:
Ethyl 2-(4'-hydroxyphenyl)-1,3-oxazole-4-carboxylate is used as a key intermediate for the synthesis of drugs with potential applications in various therapeutic areas. Its structural features allow for the creation of new molecules with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Medicinal Chemistry Research:
Ethyl 2-(4'-hydroxyphenyl)-1,3-oxazole-4-carboxylate is used as a starting material for the design and synthesis of novel compounds with potential biological activities. Researchers in medicinal chemistry utilize Ethyl 2-(4'-hydroxyphenyl)-1,3-oxazole-4-carboxylate to explore its potential in the development of new therapeutic agents, particularly in the areas of cancer, inflammation, and infectious diseases.

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 619-57-8 p-hydroxybenzamide 
• 288-42-6 oxazol 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors

In this study, a series of pyrazole derivatives containing 4-phenyl-2-oxazole moiety were designed and synthesized in a concise way, some of which exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Compound

Preparation of substituted alkenoic acids

This invention relates to a highly selective process for preparation of E-ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.

PREPARATION OF SUBSTITUTED ALKENOIC ACIDS

This invention relates to a highly selective process for preparation of E-ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.

Carbamoyl substituted oxazoles as thromboxane receptor antagonists

This invention relates to carbamoyl substituted heterocycles which are ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.