200402-45-5Relevant academic research and scientific papers
Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms
Belley, Michel,Sullivan, Richard,Reeves, Austin,Evans, Jilly,O'Neill, Gary,Ng, Gordon Y.K.
, p. 2697 - 2704 (1999)
A radioiodinated probe, [125I]-CGP 71872, containing an azido group that can be photoactivated, was synthesized and used to characterize GABA(B) receptors. Photoaffinity labeling experiments using crude membranes prepared from rat brain reveale
Ligands for expression cloning and isolation of GABAB receptors
Froestl, Wolfgang,Bettler, Bernhard,Bittiger, Helmut,Heid, Jakob,Kaupmann, Klemens,Mickel, Stuart J.,Strub, Dietrich
, p. 173 - 183 (2007/10/03)
The scope of the plenary lecture at the occasion of the Xth Meeting on Heterocyclic Structures in Medicinal Chemistry, Palermo 2002, is considerably larger than that of the main lecture at the XVIth International Symposium on Medicinal Chemistry, Bologna 2000, described by Froestl et al. in Farmaco 56 (2001) 101. Additional information is presented, in particular, on the reaction conditions for the 31 step synthesis of the combined affinity chromatography and photoaffinity radioligand [125I]CGP84963 and on the recent developments of the molecular biology of GABAB receptors.
