20041-61-6

Upstream product

• 7150-01-8 2-acetoxy-3-methoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 7740-04-7 3-methoxy-2-<(p-tolylsulfonyl)oxy>benzaldehyde 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 1027549-38-7 Toluene-4-sulfonic acid 6-formyl-2-methoxy-3-nitro-phenyl ester 

Downstream Products

• 61203-50-7 3-methoxy-2-hydroxy-4-nitrobenzoic acid 
• 736137-85-2 2-benzyloxy-3-methoxy-4-nitrobenzaldehyde 
• 72517-19-2 2,3-dihydroxy-4-nitrobenzoic acid 
• 183005-93-8 2,3-Dihydroxy-4-nitro-benzoic acid methyl ester 
• 183005-94-9 4-Ethoxycarbonylamino-2,3-dihydroxy-benzoic acid methyl ester 
• 183005-98-3 4-Amino-2,3-bis-ethoxycarbonyloxy-benzoic acid methyl ester 
• 183005-96-1 4-Ethoxycarbonylamino-2-ethoxycarbonyloxy-3-hydroxy-benzoic acid methyl ester 
• 27864-01-3 4-chloro-2,3-dihydroxybenzoic acid 
• 1279089-54-1 4-nitro-2,3-dimethoxybenzaldehyde 
• 736137-92-1 4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene 
• 736137-90-9 N⁴-(tert-butyloxycarbonyl)-2-benzyloxy-3-methoxy-N¹-(p-toluenesulfonyl)benzene-1,4-diamine 
• 736137-91-0 tert-butyl 3-benzyloxy-2-methoxy-4-(p-toluenesulfonyl)iminocyclohexa-2,5-dienylidenecarbamate 
• 736137-89-6 2-benzyloxy-3-methoxy-N¹-(p-toluenesulfonyl)benzene-1,4-diamine 
• 736137-88-5 2-benzyloxy-3-methoxy-4-nitro-N-(p-toluenesulfonyl)aniline 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE

This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.

NOVEL CYSTOBACTAMIDES

The present invention provides cystobactamides of formula (I) and the use thereof the treatment or prophylaxis of bacterial infections.

CYSTOBACTAMIDES

The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections:

NOVEL BIOACTIVE SUBSTANCE

PROBLEM TO BE SOLVED: To provide a novel compound useful as an aminopeptidase A inhibitor. SOLUTION: This invention provides a compound represented by formula (I) or salt thereof, and a pharmaceutical composition comprising the same, wherein R1

Total Synthesis and Antimicrobial Activity of Chlorocatechelin A

Chlorocatechelin A (1) is a structurally unique microbial siderophore containing two units of 4-chloro-2,3-dihydroxybenzoic acid (CDB) and a characteristic acylguanidine structure. Purification from the microbe culture is not an easy task due to the labil

AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

Synthesis of 4-chloro-7-ethoxy-2(3H)-benzoxazolone-6-carboxylic acid

As a part of metabolic studies of mosapride (1), a potential gastroprokinetic agent, the synthesis of 4-chloro-7-ethoxy-2(3H)-benzoxazolone-6-carboxylic acid (7) as a derivative of 4-amino-5-chloro-2-ethoxy-3-hydroxybenzoic acid (6), which has served a benzoic acid part of the metabolites 4 and 5, is described. Treatment of methyl 3-amino-4-substituted amino-5-chloro-2-ethoxybenzoate derivatives 11a-c with sodium nitrate in acidic medium gave the benzotriazole derivatives 13x,y instead of the objective 3-hydroxy counterpart. The synthesis of 7 started from o-vanillin acetate (15) and proceeded through the intermediates 2-hydroxy-3-methoxy-4-nitrobenzaldehyde (18), methyl 4-amino-2,3-dihydroxybenzoate (23), and methyl 7-hydroxy-2(3H)-benzoxazolone-6-carboxylate (30). Compound 30 was alternatively prepared from 23 via methyl 4-ethoxycarbonylamino-2-ethoxycarbonyloxy-3-hydroxybenzoate (29), which is the product resulting from the migration of the ethoxycarbonyl group of methyl 4-amino-2,3-diethoxycarbonyloxybenzoate (27).

Dihydroxynitrobenzaldehydes and Hydroxymethoxynitrobenzaldehydes: Synthesis and Biological Activity as Catechol-O-methyltransferase Inhibitors

A series of nitro derivatives of dihydroxy- and hydroxymethoxybenzaldehyde was synthesized and tested as potential inhibitors of partially purified pig liver catechol-O-methyltransferase (COMT).All the dihydroxynitrobenzaldehydes prepared were potent inhibitors of COMT, but only one hydroxymethoxynitrobenzaldehyde (3-hydroxy-4-methoxy-5-nitrobenzaldehyde) showed activity as a COMT inhibitor.Although previously reported data showed that the presence of electron-withdrawing substituents at position 5 seemed to be very important for activity as COMT inhibitor, our results suggest that the requirement necessary to enhance the activity of the dihydroxynitrobenzaldehyde derivatives toward COMT is the presence of the nitro group in a position ortho with respect to one hydroxyl group.The assayed compounds showed a reversible inhibition of COMT, which was mixed for all the dihydroxynitro derivatives but noncompetitive for 3-hydroxy-4-methoxy-5-nitrobenzaldehyde when pyrocatechol was the variable substrate and uncompetitive in all the inhibitors with respect to S-adenosyl-L-methionine.