200411-28-5

Upstream product

• 80696-28-2 (2R)-2-amino-2-butyl-1-ethanol 
• 1499-21-4 Diphenylphosphinic chloride 
• 582314-55-4 (2S)-1-azido-(+)-3-O-(diphenylphosphoryl)propane-2,3-diol 
• 582314-54-3 (2R)-(+)-(O-diphenylphosphoryl)-2-(hydroxymethyl)oxirane 
• 927-77-5 n-propylmagnesium bromide 
• 582314-57-6 (2R)-N,O-bis(diphenylphosphinyl)-2-(hydroxymethyl)aziridine 

Downstream Products

• 582314-58-7 (2R)-1-cyclopentyl-2-[(diphenylphosphoryl)amino]hexane 
• 200411-32-1 (1R,3R,5S,8aS)-1-Benzenesulfonyl-3-butyl-5-methyl-octahydro-indolizine 
• 200411-30-9 Acetic acid (R)-2-benzenesulfonyl-4-benzoylamino-1-pent-4-enyl-octyl ester 
• 200411-27-4 5-((2S,3R,5R)-3-Benzenesulfonyl-1-benzyl-5-butyl-pyrrolidin-2-yl)-pentan-2-one 
• 200411-25-2 ((2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidin-1-yl)-phenyl-methanone 
• 1038750-64-9 (2S,3R,5R)-3-Benzenesulfonyl-1-benzyl-5-butyl-2-pent-4-enyl-pyrrolidine 
• 200411-29-6 N-[(R)-1-(2-Benzenesulfonyl-ethyl)-pentyl]-benzamide 
• 1038750-62-7 (2S,3R,5R)-3-Benzenesulfonyl-5-butyl-2-pent-4-enyl-pyrrolidine 

Relevant academic research and scientific papers

Preparation and ring-opening reactions of N,O-bis(diphenylphosphinyl) hydroxymethylaziridine ('Di-Dpp')

N,O-bis(diphenylphosphinyl)-2-(hydroxymethyl)aziridine ('DiDpp', 1) is efficiently prepared from 2-aminoethane-1,3-diol: this activated aziridine undergoes two sequential reactions with copper(I)-modified Grignard reagents, yielding α-branched N-Dpp amines in good yield.

5-endo-trig Cyclisations in heterocycle synthesis: Enantiospecific synthesis of (+)-monomorine I

The indolizidine alkaloid monomorine I is synthesised from D-norleucinol using 5-endo-trig cyclisation and intramolecular reductive amination as the key ring-forming steps.