200417-08-9Relevant academic research and scientific papers
Copper-catalyzed C-N cross-coupling of substituted 2-halobenzoates with secondary acyclic amides
Wang, Man-Gang,Yu, Hua,Wu, Jun,Shang, Zhi-Cai
supporting information, p. 1955 - 1964 (2013/07/26)
The copper-catalyzed C-N cross-coupling of poorly nucleophilic acyclic secondary amides with sterically hindered substituted 2-halobenzoates has been demonstrated with 1,4-dimethyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one (DMBDO) as ligands for the first time. The protocol is effective for the synthesis of hindered tertiary amides. We also found that the alkoxycarbonyl (CO2R) group has a strong ortho-substituent effect on a Goldberg-type C-N coupling reaction. Georg Thieme Verlag Stuttgart. New York.
