6833-18-7

Usage

InChI:InChI=1/C14H13NO/c1-11-7-9-12(10-8-11)14(16)15-13-5-3-2-4-6-13/h2-10H,1H3,(H,15,16)

Upstream product

• 2998-92-7 (Z)-phenyl(p-tolyl)methanone oxime 
• 2998-91-6 p-tolyl phenyl ketoxime 
• 14338-21-7 tri-(4-methylphenyl)aluminum 
• 103-71-9 phenyl isocyanate 
• 108-88-3 toluene 
• 874-60-2 4-methyl-benzoyl chloride 
• 62-53-3 aniline 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 104-85-8 para-methylbenzonitrile 
• 1900-85-2 phenyl p-methylbenzoate 
• 13222-85-0 p-methylbenzoic anhydride 
• 10347-11-2 4-(methylbenzoyl)imidazoline 
• 15818-64-1 N-(4-methylbenzyl)aniline 
• 31614-66-1 tributyl(p-tolyl)stannane 

Downstream Products

• 68587-15-5 (4-(dimethylamino)phenyl)(p-tolyl)methanone 
• 25110-49-0 4-methyl-N,N'-diphenyl-benzamidine 
• 5866-76-2 (4-Methyl-benzoyl)-phenyl-carbamic acid isopropyl ester 
• 40686-26-8 4-Methyl-N,N-diphenylbenzamide 
• 1027895-70-0 2-[Hydroxy-(3-methoxy-phenyl)-methyl]-4-methyl-N-phenyl-benzamide 
• 329969-90-6 [1-Benzotriazol-1-yl-1-p-tolyl-meth-(E)-ylidene]-phenyl-amine 
• 34916-13-7 N-Phenyl-p-toluol-carboximidsaeure-chlorid 
• 161768-67-8 N-[(Z)-1H-1,2,3-benzotriazol-1-yl(4-methylphenyl)methylidene]aniline 
• 93-98-1 N-phenyl benzoyl amide 
• 5436-83-9 N-benzyl-4-methylbenzamide 
• 294644-43-2 N¹-{[(methyl)(phenyl)amino](selenocarbonyl)}-4-methyl-N²-phenylbenzimidamide 
• 294644-59-0 ethyl 4-(4-methylphenyl)-2-(morpholin-4-yl)-1,3-selenazole-5-carboxylate 
• 294644-40-9 4-methyl-N²-[(morpholin-4-yl)(selenocarbonyl)]-N¹-phenylbenzimidamide 

Relevant academic research and scientific papers

Water-Soluble Non-Classical Benzene Mimetics

A new generation of saturated benzene mimetics, 2-oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2-oxabicyclo[2.1.1]hexanes revea

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.

Fe-mediated synthesis of: N -aryl amides from nitroarenes and acyl chlorides

Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale.

Selective hydrogenation dehalogenation method of ortho-halogenated acylaniline

The invention discloses a selective hydrogenation dehalogenation method of copper-catalyzed ortho-halogenated acylaniline. The method comprises the following steps: by using ortho-halogenated acylaniline as a starting raw material and copper acetylacetonate/vasicine as a catalyst, adding an organic alkali, reacting in an alcoholic solution at 80-100 DEG C for 12 hours, and regioselectively catalytically hydrogenating ortho-bromine and iodine atoms. The preparation method has the characteristics of simplicity and convenience in operation, wide substrate application range, low cost, high regioselectivity and the like, and has practicability.

Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source

In present work, we have explored a Cu(acac)2/vasicine-catalyzed regioselective hydrodehalogenation methodology of o-haloanilides using EtOH as hydrogen source and solvent. The catalytic system could selectively dehalogenate 2-Br and 2-I, and features regioselective, efficient and functional group tolerance.

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF 2as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Iron-catalyzed oxidative amidation of acylhydrazines with amines

A new approach for amide bond formation via a mild and efficient Iron-catalyzed cross-coupling reaction of acylhydrazines and amines using TBHP as oxidant is described. This protocol is compatible with a wide range of amines and acylhydrazines. In addition, the synthetic application of the reaction is presented.

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.