200417-68-1 Usage
Uses
Used in Biochemical Research:
ThyMine-13C1 is used as a biochemical research tool for studying the incorporation and metabolism of thymidine in biological systems. The carbon-13 isotope allows for the tracking and analysis of thymidine's metabolic pathways and its role in DNA synthesis.
Used in Molecular Biology:
In molecular biology, ThyMine-13C1 is used as a tracer molecule to investigate the mechanisms of DNA replication and repair. The incorporation of the 13C-labeled thymidine into newly synthesized DNA strands enables researchers to monitor the process and gain insights into the fidelity and efficiency of these essential cellular functions.
Used in Metabolomics:
ThyMine-13C1 is employed as a metabolite in metabolomics studies, where it helps in the identification and quantification of thymidine and its related metabolites in biological samples. The use of the stable isotope allows for accurate mass spectrometry analysis, providing precise measurements and enhancing the reliability of the data obtained.
Used in Pharmaceutical Development:
ThyMine-13C1 is utilized in the development of pharmaceuticals targeting DNA-related processes, such as antiviral and anticancer drugs. The isotopically labeled compound can be used to study the interactions between these drugs and their molecular targets, leading to the optimization of drug efficacy and selectivity.
Used in Radiotracer Studies:
In radiotracer studies, ThyMine-13C1 can be used as a precursor for the synthesis of radiolabeled thymidine analogs. These radiolabeled compounds are valuable for investigating the biodistribution, pharmacokinetics, and mechanism of action of potential therapeutic agents in preclinical and clinical research settings.
Check Digit Verification of cas no
The CAS Registry Mumber 200417-68-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,4,1 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 200417-68:
(8*2)+(7*0)+(6*0)+(5*4)+(4*1)+(3*7)+(2*6)+(1*8)=81
81 % 10 = 1
So 200417-68-1 is a valid CAS Registry Number.
200417-68-1Relevant academic research and scientific papers
Singh, Palwinder,Kumar, Arun,Kaur, Sukhmeet,Singh, Amrinder
, p. 9961 - 9964 (2015)
Inspired by TSase catalysis for dUMP conversion to dTMP, a biomodel reagent is developed. The presence of NH2, Gly-(S)-Cys and (S)-oxiran methyl, at C5, C4 and N-10 of acridine, respectively, in addition to the pH of the reaction mixture, allows for good complementary inter- and intra-molecular interactions and chiral discrimination for the reagent to achieve conversion of uracil to thymine.
Synthesis of the isotopically labeled JAK1/3 inhibitor [D7]-R545 and its oxidative metabolite [D7]-R935: Protecting group-directed regioselective bromination to access 3,4,5-substituted anilines
Heckrodt, Thilo J.,Chen, Yan,Singh, Rajinder
, p. 2385 - 2399 (2019/03/20)
An extensive medicinal chemistry campaign and subsequent SAR studies led to the discovery of the highly potent and selective JAK1/3 inhibitor R545. To support advanced pre-clinical DMPK studies of R545, the isotopically labeled versions of the drug and its metabolite R935 were required. Herein, we describe the development of synthetic routes to deuterium-labeled [D7]-R545 and its oxidative metabolite [D7]-R935. Deuterium atoms were introduced at several sites in the target molecules by employing a convergent synthesis strategy. The desired regiochemistry at the right-hand side of [D7]-R935 was established via a newly discovered protecting group-directed bromination. The described synthetic approach gave rise to the desired deuterium-labeled target compounds and sufficient quantities were synthesized to enable pre-clinical DMPK studies.
