200435-33-2Relevant academic research and scientific papers
Synthesis, redox properties, and conformational analysis of vicinal disulfide ring mimics
Ruggles, Erik L.,Deker, P. Bruce,Hondal, Robert J.
scheme or table, p. 1257 - 1267 (2009/05/07)
A vicinal disulfide ring (VDR) results from disulfide-bond formation between two adjacent cysteine residues. This eight-membered ring is a rare motif in protein structures and is functionally important to those few proteins that posses it. This article focuses on the construction of strained and unstrained VDR mimics, discernment of the preferred conformation of these mimics, and the determination of their respective disulfide redox potentials.
1,2-dithia-5-azacyclooctan-6-one and related compounds: Synthesis and conformation
Cepas, Susana Caveda,North, Michael
, p. 16859 - 16866 (2007/10/03)
The first synthesis of 1,2-dithia-5-azacyclooctan-6-one 11, the parent member of a heterocyclic ring synthesis is reported. Compound 11 was found by hoe experiments to exist in a conformation with a trans-amide bond. The substituted derivatives 12 and 13 were also prepared and compound 12 was found to possess a trans-amide bond whilst for compound 13 three conformations were identified with the major conformer possessing a cis- amide bond.
