20045-77-6

Usage

Uses

Used in Cardiology:
(S)-Methyl 2-(methylamino)propanoate hydrochloride is utilized as an antiarrhythmic agent for the treatment of ventricular arrhythmias. It is particularly beneficial for patients with structural heart disease or those who have experienced a myocardial infarction, helping to regulate abnormal heart rhythms and improve cardiac function.
Used in Neurology:
Mexiletine, as (S)-Methyl 2-(methylamino)propanoate hydrochloride, is being explored for its potential application in neuropathic pain management. Its mechanism of action in blocking sodium channels may contribute to alleviating pain symptoms associated with various neurological conditions.
Used in Neuromuscular Disorders:
In the field of neuromuscular disorders, (S)-Methyl 2-(methylamino)propanoate hydrochloride is under investigation for its possible role in treating myotonic dystrophy. (S)-Methyl 2-(methylamino)propanoate hydrochloride's impact on sodium channels could offer therapeutic benefits in managing the symptoms of this genetic disorder.

Upstream product

• 67-56-1 methanol 
• 65672-32-4 N-methyl-L-alanine hydrochloride 

Downstream Products

• 19794-10-6 (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 
• 1154580-17-2 C₁₂H₁₄N₂O₆ 
• 1233333-51-1 (S)-2-({3'-[(R)-1-(4-chloro-3-methyl-phenyl)-ethylamino]-3,5-dimethyl-biphenyl-4-carbonyl}-methyl-amino)-propionic acid methyl ester 
• 1233333-54-4 (S)-2-[(4-bromo-2-methyl-benzoyl)-methyl-amino]propionic acid methyl ester 
• 890532-47-5 C₁₂H₁₄ClFN₂O₄ 
• 116871-78-4 Z-Phe-NMeAla-OMe 
• 122237-12-1 Boc-D-Phe-L-Ala-OMe 
• 78867-92-2 (S)-2-[((S)-2-Benzoylamino-propionyl)-methyl-amino]-propionic acid methyl ester 
• 15136-29-5 (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)propanoate 
• 78867-93-3 N-benzoyl-D-alanyl-L-N-methylalanine methyl ester 
• 1021691-21-3 N-[(4-chloro-2-nitrophenyl)methyl]-N-methyl-L-alanine methyl ester 
• 1382351-59-8 Boc-L-Tyr-N-Me-L-Ala-OMe 

Relevant academic research and scientific papers

Fluorogenic peptide substrates for serine and threonine phosphatases

Figure presented A new fluorescent assay for Ser/Thr protein phosphatases has been developed. Hydrolysis of a phosphoSer residue liberates the Ser hydroxyl group, which induces a cyclization reaction on the N-terminal carbamate and releases a fluorescent reporter. Sequence selectivity is observed using several peptide substrates against alkaline phosphatase (ALP), bacteriophage protein phosphatase (-PPase), and vaccinia H1 related phosphatase (VHR). These studies suggest that the assay could be a useful tool for profiling the substrate specificities of medicinally important phosphatases.