200501-09-3Relevant articles and documents
Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
Uoto, Kouichi,Ohsuki, Satoru,Takenoshita, Haruhiro,Ishiyama, Takashi,Iimura, Shin,Hirota, Yasuhide,Mitsui, Ikuo,Terasawa, Hirofumi,Soga, Tsunehiko
, p. 1793 - 1804 (2007/10/03)
To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a