20051-87-0

Basic information

• Product Name: (+)-Predicentrine
• CAS NO: 20051-87-0
• Molecular Weight: 341.407
• Mol File: 20051-87-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-Predicentrine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-Predicentrine(20051-87-0)
• EPA Substance Registry System: (+)-Predicentrine(20051-87-0)

Safety Data

• Hazardous Substances Data: 20051-87-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 476-70-0 boldine 
• 98-04-4 phenyltrimethylammonium iodide 
• 186581-53-3 diazomethane 

Relevant articles and documents

Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats

The antihyperglycemic actions of some aporphines and their derivatives in normal Wistar, streptozotocin (STZ)-induced diabetic (IDDM) and nicotinamide-STZ induced diabetic (NIDDM) rats were investigated in this study. These compounds included thaliporphine, glaucine, boldine, N-methyllaurotetanine, and predicentrine and the derivatives, N-[2-(2-methoxyphenoxy)ethyl]-norglaucine and diacetyl-N-allylsecoboldine. Bolus intravenous injection of these compounds decreased the plasma glucose levels in a dose-dependent manner in both normal and diabetic rats. Among them, thaliporphine was found to have the most potent antihyperglycemic effect in both NIDDM and IDDM diabetic rats. It was found that thaliporphine could stimulate the release of insulin in both normal and diabetic rats, and a dose of 1 mg per kg thaliporphine could significantly attenuate the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Similar treatment with thaliporphine significantly increased the skeletal muscle glycogen synthesis in both normal and diabetic rats. Hence, the hypoglycemic effect of thaliporphine in diabetic rats could be attributed to the stimulation of insulin release and the increase of glucose utilization. Georg Thieme Verlag KG Stuttgart.

Semisynthetic studies on and biological evaluation of N-methyllaurotetanine analogues as ligands for 5-HT receptors

N-Methyllaurotetanine (1) has been reported to display good affinity for the 5-HT1A receptor, but no structure-affinity studies have been performed to date. The commercially available alkaloid boldine (2) was used as the starting material for s