20052-02-2Relevant academic research and scientific papers
Conventional and microwave-assisted syntheses and solid-state structure of new coumarins and angelicins
Hejchman, Elzbieta,Trykowska Konc, Joanna,MacIejewska, Dorota,Kruszewska, Hanna
, p. 2392 - 2402 (2011)
New derivatives of coumarin and angelicin, 8-acetyl-7-cyanomethoxy-4- methyl-chromen-2-one (1), 8-acetyl-7-ethoxycarbonylmethoxy-4-methyl-chromen-2- one (2), 8-cyano-4,9-dimethyl-2H-furo[2,3-h]-1-chromen-2-one (3), and 8-ethoxycarbonyl-4,9-dimethyl-(2H-furo[2,3-h]-1-chromen-2-one) (4) were obtained by conventional synthesis and by efficient and high-yielding microwave-assisted synthesis. The solid structures were analyzed using 13C cross polarization/magic angle spinning (CP/MAS) NMR spectroscopy. Compounds 1 and 3 were evaluated for potential anticancer activity in an in vitro screening panel of 60 human tumor cell lines. Selected leukemia, non-small-cell lung, and renal cancer lines showed promising sensitivity to these compounds. Additionally, compound 4 was shown to inhibit growth of Gram-positive strains.
New synthesis of 8-alkoxycarbonylangelicins
Tolmachev,Podkhalyuzina,Kuznetsova,Traven'
, p. 1008 - 1012 (2007/10/03)
A new procedure was developed for the synthesis of 8-alkoxycarbonylangelicins by base-catalyzed cyclization of ortho-acyl(hydroxy)coumarins with haloacetic acid esters. The procedure was successfully applied to prepare a series of new 8-alkoxycarbonyl-and 8-acylangelicins.
