20067-97-4

Upstream product

• 20068-09-1 (Z)-4-phenylbut-3-enenitrile 
• 20068-10-4 (E)-4-phenyl-3-butenenitrile 
• 100-44-7 benzyl chloride 
• 107-13-1 acrylonitrile 
• 300-57-2 allylbenzene 
• 20067-98-5 trans-4-phenyl-2-butenenitrile 

Downstream Products

• 20068-09-1 (Z)-4-phenylbut-3-enenitrile 
• 20068-10-4 (E)-4-phenyl-3-butenenitrile 
• 20067-98-5 trans-4-phenyl-2-butenenitrile 
• 1025483-29-7 methyl 2-cyano-4-phenylbutanoate 

Relevant academic research and scientific papers

New results on the functionalization of terminal alkenes by cross- metathesis reactions

The ruthenium-catalyzed reaction of allylbenzene with several types of alkene provides good yields of the cross-metathesis products regardless of the structural characteristics of the alkene.

Comparative investigation of Hoveyda-Grubbs catalysts bearing modified N-heterocyclic carbene ligands

This paper reports the structural modification of Hoveyda-Grubbs complexes through the introduction of either an N-alkyl-N′-mesityl heterocyclic carbene, an N-alkyl-N′-(2,6-diisopropylphenyl) heterocyclic carbene, or an N-alkyl-N′-alkyl heterocyclic carbe

Olefin metathesis catalysts containing acyclic diaminocarbenes

The first examples of ruthenium-based olefin metathesis catalysts containing acyclic diaminocarbene (ADC) ligands are reported. Complexes of the type (ADC)(SIMeS)Cl2Ru=CHPh and (ADC)Cl2Ru=CH(2- isopropoxy)Ph (ADC = N,N'-dimethylformamidin-2-ylidene or N,N'-bis(2,6-di- isopropylphenyl)-N,N'-dimethylformamidin-2-ylidene; SIMes = 1,3- dimesitylimidazolin-2-ylidene) were synthesized and studied in solution as well as in the solid state. Depending on their N-substituents and the metal center to which they were coordinated, the aforementioned ADC ligands were found to adopt different conformations. Preliminary investigations revealed that these Ru complexes exhibited high catalytic activities in a variety of olefin metathesis reactions at elevated temperatures and afforded cross-metathesis products with significantly lower E:Z ratios than catalysts containing analogous N-heterocyclic carbene ligands.

Chloro-substituted Hoveyda-Grubbs ruthenium carbene: Investigation of electronic effects

A series of applications of cross and ring-closing metathesis has been made to investigate the application profile of the chloro-substituted Hoveyda-Grubbs ruthenium carbene in order to evaluate electronic effects resulting from the introduction of a chlorine atom para to the isopropoxy moiety of its parent catalyst.

Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts

The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least

Highly Reactive Metallic Nickel: Reductive Homocoupling Reagent for Benzylic Mono- and Polyhalides

Metallic nickel, prepared by the reduction of nickel halides with lithium in glyme using naphthalene as an electron carrier, was found to be a useful reagent for the homocoupling of benzylic mono- and polyhalides.Benzyl halides reacted with metallic nickel at room temperature to give the corresponding 1,2-diarylethanes in good to high yields and functional groups on the aromatic ring such as methoxy, chloro, bromo, nitro, cyano, and alkoxycarbonyl groups were not affected under the conditions employed.Benzylic monohalides (1-(chloromethyl)- or 2-(bromomethyl)naphthalene, chlorodiphenylmethane, and 9-bromofluorene) also underwent coupling reactions with metallic nickel at room temperature to give the corresponding ethane derivatives.On the other hand, benzylic di- and trihalides such as α,α-dibromotoluene and α,α,α-trichlorotoluene yielded mixtures of cis and trans isomers of substituted ethenes.The intermediate of the reaction, benzylnickel complex, was trapped with electron deficient olefins such as methyl acrylate and acrylonitrile.