1025483-29-7Relevant articles and documents
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00320; 00327, (2021/09/11)
The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
Regioselective Hydrogenolysis of Donor-Acceptor Cyclopropanes with Zn-AcOH Reductive System
Ivanov, Konstantin L.,Villemson, Elena V.,Latyshev, Gennadij V.,Bezzubov, Stanislav I.,Majouga, Alexander G.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
, p. 9537 - 9549 (2017/09/23)
A convenient low-cost method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH reductive system was developed. The general character of the method was displayed via efficient reduction of a representative series of 2-(het)arylcyclopropane-1,1-diesters as well as donor-acceptor cyclopropanes with other types of electron-withdrawing activating groups. This method opens a rapid access to γ-substituted propyl-1,1-diesters, ketoesters, cyanoesters, cyanoamides, dinitriles, etc., many of which are not readily accessible with alternative methods. The utility of the synthesized compounds was demonstrated by transforming them into valuable acyclic and cyclic compounds (including pharmacologically relevant carbazoles, δ-lactams, and oxindole derivatives).
Atom- and step-economical preparation of reduced knoevenagel adducts using CO as a deoxygenative agent
Kolesnikov, Pavel N.,Usanov, Dmitry L.,Barablina, Evgeniya A.,Maleev, Victor I.,Chusov, Denis
supporting information, p. 5068 - 5071 (2014/12/11)
A highly efficient one-step Rh-catalyzed preparation of reduced Knoevenagel adducts of various aldehydes and ketones with active methylene compounds has been developed. The protocol does not require an external hydrogen source and employs carbon monoxide
