200726-73-4

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 200726-70-1 phenylmethyl-6-deoxy-5-C-methyl-4-O-methyl-L-lyxo-hexopyranoside 
• 107739-83-3 (+)-6-deoxy-5-C,4-O-dimethyl-L-xylo-hexopyranose 
• 264891-36-3 L-lyxo-O²,O³-isopropylidene-5,O⁴-dimethyl-6-deoxy-hexonic acid-lactone 
• 101967-82-2 4-O-methyl-5,5-di-C-methyl-2,3-O-(1-methylethylidene)-L-lyxopyranose 
• 245729-75-3 (R)-1-((4S,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methoxy-2-methyl-propan-2-ol 

Downstream Products

• 200726-75-6 3-(5-methyl-1-H-pyrrole-2-carboxylate) of phenylmethyl-6-deoxy-5-C-methyl-4-O-methyl-L-lyxo-hexopyranoside 
• 245729-78-6 5-methyl-1H-pyrrole-2-carboxylic acid 6-(4-benzhydryloxy-8-methyl-2-oxo-2H-chromen-7-yloxy)-3-methoxy-2,2-dimethyl-5-(tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yl ester 
• 245729-77-5 5-methyl-1H-pyrrole-2-carboxylic acid 6-(4-benzhydryloxy-8-methyl-2-oxo-2H-chromen-7-yloxy)-5-hydroxy-3-methoxy-2,2-dimethyl-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Aromatic derivatives substituted by a ribose, their method of preparation and application as medicine

A subject of the invention is the compounds of formula (I): R1=H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R2=H, Hal, R3=H, alkyl, Hal, Rg and Rh: H, alkyl, aryl heterocycle, R5=H or O-alkyl, R6=alkyl or CH2—O-alkyl, R7=H or alkyl. The compounds of formula (I) have antibiotic properties.

Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B

The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3- acylamino residue (3-NHCOR) of coumarin drags with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and CONH