20073-81-8

Basic information

• Product Name: N,N'-Dihydroxyisophthalamide
• Synonyms: 1,3-Benzenedi-N-hydroxycarboxamide;Isophthaldihydroxamic acid;Isophthalohydroxamic acid;N,N'-Dihydroxy-1,3-benzenedicarboxamide;N,N'-Dihydroxyisophthalamide;1-N,3-N-dihydroxybenzene-1,3-dicarboxamide
• CAS NO: 20073-81-8
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Mol File: 20073-81-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N'-Dihydroxyisophthalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Dihydroxyisophthalamide(20073-81-8)
• EPA Substance Registry System: N,N'-Dihydroxyisophthalamide(20073-81-8)

Safety Data

• Hazardous Substances Data: 20073-81-8(Hazardous Substances Data)

Upstream product

• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 1459-93-4 dimethyl Isophthalate 
• 121-91-5 isophthalic acid 
• 65789-71-1 α,α,α,α',α',α'-hexamethoxy-m-toluene 
• 881-99-2 1,3-bis-trichloromethyl-benzene 

Downstream Products

• 15568-83-9 5,5,5',5'-tetramethyl-3,3'-m-phenylene-bis-[1,4,2]dioxazole 
• 108-45-2 m-phenylenediamine 
• 40069-03-2 O,O'-Bis(diphenylcarbamyl)-terephthalohydroxamat 

Relevant articles and documents

A three dimensional porous metal-organic framework [Fe4L 6·(DMF)3·(H2O)10] constructed from neutral discrete Fe4L6 pyramids [H 2L = 1,3-benzodihydroxamix acid]

A 3-D porous zeolite-like metal-organic framework surviving guest removal is assembled from a well-defined tetrahedral Fe4L6 cavity by the cooperativity of hydrogen bonds and π-π stacking.

Preparation method of a plurality of (hetero) aromatic polyamines

The invention relates to the field of organic functional new material chemicals, and discloses a novel process technology for preparing a plurality of (hetero) aromatic polyamines through corresponding (hetero) aromatic polyfunctional hydroxamic acids (hydroxamic acid) before (re-arrangement). These (hetero) aromatic polyamines are well-known dyes and pigment and pharmaceutical pesticide-related fields of very wide range of critical fine chemical materials.

NADP-dependent glutamate dehydrogenases in a dimorphic zygomycete Benjaminiella poitrasii: Purification, characterization and their evaluation as an antifungal drug target

Background: It has been reported that the genes coding for NADP-dependent glutamate dehydrogenases (NADP-GDHs) showed a cause-effect relationship with Yeast-Hypha (Y[sbnd]H) reversible transition in a zygomycete Benjaminiella poitrasii. As Y[sbnd]H transition is significant in human pathogenic fungi for their survival and proliferation in the host, the NADP-GDHs can be explored as antifungal drug targets. Methods: The yeast-form specific BpNADPGDH I and hyphal-form specific BpNADPGDH II of B. poitrasii were purified by heterologous expression in E. coli BL-21 cells and characterized. The structural analogs of L-glutamate, dimethyl esters of isophthalic acid (DMIP) and its derivatives were designed, synthesized and screened for inhibition of NADP-GDH activity as well as Y[sbnd]H transition in B. poitrasii, and also in human pathogenic Candida albicans strains. Results: The BpNADPGDH I and BpNADPGDH II were found to be homo-hexameric proteins with native molecular mass of 282 kDa and 298 kDa, respectively and subunit molecular weights of 47 kDa and 49 kDa, respectively. Besides the distinct kinetic properties, BpNADPGDH I and BpNADPGDH II were found to be regulated by cAMP-dependent- and Calmodulin (CaM) dependent- protein kinases, respectively. The DMIP compounds showed a more pronounced effect on H-form specific BpNADPGDH II and inhibited Y[sbnd]H transition as well as growth in B. poitrasii and C. albicans strains. Conclusion: The present study will be useful to design and develop antifungal drugs against dimorphic human pathogens using glutamate dehydrogenase as a target. Significance: Glutamate dehydrogenases can be explored as a target against human pathogenic fungi.