200863-83-8Relevant articles and documents
The synthesis of bisanthraquinone derivatives as DNA bisintercalating agents
Ge, Ping,Russell, Richard A.
, p. 17477 - 17488 (2007/10/03)
The linked bisanthraquinone derivatives 4a-c were synthesized as DNA bisintercalating agents. Starting from the aldehyde 7, the linking chain was introduced via a Grignard reaction to afford the ethers 9a-c. Subsequent anodic oxidation of these products, followed by annelation with the anion of phthalide 5 afforded the linked anthraquinones 12. The target compounds were then obtained by selective esterification with the acid 14, followed by deprotection with anhydrous hydrogen chloride.