2009-89-4Relevant academic research and scientific papers
The synthesis of novel oxime ethers and their effects on the senescence of cut carnation flowers
Zeng, Zhen,Jiang, Hong,Zhang, Haoyong,Jiang, Zhenhua
scheme or table, p. 463 - 470 (2012/05/20)
The high levels of ethylene in plants are involved in a range of harmful effects, such as the senescence of plants and the rotting of fruits. A series of novel oxime ethers were synthesized to counteract the ethylene effects. Their structures were characterized by IR, MS, and 1H NMR, and their effects on the senescence of cut carnation flowers were investigated. The results show that all of the target compounds extended the vase life of cut carnation, especially for compound 3i, which prolonged the vase life of cut carnation flowers to about 11 days, nearly 75% longer vase life compared to the control groups. Most of them were more effective than AgNO3 and aminooxyacetic acid. Springer Science+Business Media B.V. 2011.
Camptothecin derivatives as chemoradiosensitizing agents
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Page/Page column 34, (2008/06/13)
Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
On the absolute stereochemistry of the photochemical rearrangement of 2,5-cyclohexadienones to lumiketones
Schuster, David I.,Vasanth Prabhu,Smith, Karl J.,van Der Veen, James M.,Fujiwara, Hideji
, p. 3495 - 3507 (2007/10/02)
Specification of the absolute configurations of starting material and product in the photochemical rearrangement of a 2,5-cyclohexadienone to a bicyclo[3.1.0]hexen-2-one (lumiketone) permits unambiguous determination of the stereochemistry at two crucial stages in the generally accepted reaction mechanism, namely the electrocyclic ring closure to give a 3,5-bonded intermediate, and the subsequent [1,4]-sigmatropic shift. The stereochemical course of the latter process in turn allows specification of whether the rearrangement is occurring directly from an electronically excited intermediate or a ground state zwitterion. An unconstrained monocyclic chiral cyclohexadienone has been studied in which steric constraints are minimal, and in which the system should have free choice of available pathways. The absolute configuration of the resolved dienone was determined by X-ray crystallographic analysis of a derivative containing a chiral center of known configuration. The absolute configuration of the resultant optically active diastereomeric lumiketones has been assigned from the Cotton effects observed on the corresponding dihydrolumiketones, assuming these chiroptical effects are governed by a normal Octant Rule instead of the Inverse Octant Rule which empirically correlates such data for cyclopropyl ketones lacking polarizable substituents. The limitations on these assignments are discussed, as well as alternative efforts to obtain completely unambiguous stereochemical assignments for the lumiketones. On the basis of these assignments, it is concluded that the sigmatropic shift proceeds with inversion of configuration at the migrating carbon, consistent with reaction via a ground state zwitterion.
