2009273-71-4Relevant articles and documents
Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Di Lello, Paola,Pastor, Richard,Murray, Jeremy M.,Blake, Robert A.,Cohen, Frederick,Crawford, Terry D.,Drobnick, Joy,Drummond, Jason,Kategaya, Lorna,Kleinheinz, Tracy,Maurer, Till,Rougé, Lionel,Zhao, Xianrui,Wertz, Ingrid,Ndubaku, Chudi,Tsui, Vickie
, p. 10056 - 10070 (2017)
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein we describe the biophysical, biochemical, and comput
USP7 INHIBITOR COMPOUNDS AND METHODS OF USE
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, (2016/10/11)
2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
