200930-72-9Relevant articles and documents
Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines
Duong, Vincent K.,Horan, Alexandra M.,McGarrigle, Eoghan M.
supporting information, p. 8451 - 8457 (2020/11/12)
An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodology permits selective introduction of functional groups from commercially available pyridyl halides, furnishing symmetrical and unsymmetrical 2,2′- A nd 2,3′-bipyridines. Iterative application of the methodology enabled the synthesis of a functionalized terpyridine with three different pyridine components.
Nucleophilic substitutions at the pyridine ring. Conformational preference of the products and kinetics of the reactions of 2-chloro-3-nitro- and 2-chloro-5-nitro-pyridines with arenethiolates
Hamed, Ezzat A.,El-Bardan, Ali A.,Saad, Esmat F.,Gohar, Gamal A.,Hassan, Ghada M.
, p. 2415 - 2421 (2007/10/03)
The reactions of 2-chloro-3-nitropyridine 1 and 2-chloro-5-nitropyridine 2 with arenethiolates 3a-i result in arylthio-dechlorination to give 2-arylthio-3-nitropyridines 4a-i and 2-arylthio-5-nitropyridines 5a-i. A 1H NMR study and AM1 calculat