91974-22-0

Basic information

• Product Name: 2-[(4-METHYLPHENYL)SULFONYL]-5-NITROPYRIDINE
• Synonyms: 4-METHYLPHENYL 5-NITRO-2-PYRIDINYL SULFONE;2-[(4-METHYLPHENYL)SULFONYL]-5-NITROPYRIDINE;2-(4-methylbenzenesulfonyl)-5-nitropyridine
• CAS NO: 91974-22-0
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.28
• Mol File: 91974-22-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(4-METHYLPHENYL)SULFONYL]-5-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-METHYLPHENYL)SULFONYL]-5-NITROPYRIDINE(91974-22-0)
• EPA Substance Registry System: 2-[(4-METHYLPHENYL)SULFONYL]-5-NITROPYRIDINE(91974-22-0)

Safety Data

• Hazardous Substances Data: 91974-22-0(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 200930-72-9 5-nitro-2-(p-tolylthio)pyridine 

Relevant articles and documents

Palladium(II)-Catalyzed Synthesis of Sulfinates from Boronic Acids and DABSO: A Redox-Neutral, Phosphine-Free Transformation

A redox-neutral palladium(II)-catalyzed conversion of aryl, heteroaryl, and alkenyl boronic acids into sulfinate intermediates, and onwards to sulfones and sulfonamides, has been realized. A simple Pd(OAc)2 catalyst, in combination with the sulfur dioxide surrogate 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO), is sufficient to achieve rapid and high-yielding conversion of the boronic acids into the corresponding sulfinates. Addition of C- or N-based electrophiles then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, two-step process.