200933-25-1

Basic information

• Product Name: (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL
• Synonyms: (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL
• CAS NO: 200933-25-1
• Molecular Formula: C₇H₈N₂O₄
• Molecular Weight: 184.14942
• Mol File: 200933-25-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL(200933-25-1)
• EPA Substance Registry System: (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL(200933-25-1)

Safety Data

• Hazardous Substances Data: 200933-25-1(Hazardous Substances Data)

Usage

General Description

(METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is a chemical compound with the molecular formula C8H8N2O4. It is a derivative of 3-nitropyridine and contains a methoxy group. (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and organic compounds. It can also be used as a reagent in chemical reactions and as a precursor for the preparation of other organic molecules. The presence of the nitro group in the molecule makes it a potentially hazardous chemical and proper safety precautions should be taken when handling and storing it. Overall, (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is an important intermediate in organic synthesis with various industrial applications.

Upstream product

• 67-56-1 methanol 
• 18699-87-1 2-methyl-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 150281-83-7 2-ethenyl-3-nitropyridine 

Downstream Products

• 1094619-87-0 (R)-6-(3-nitropyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 
• 1094619-66-5 (R)-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 
• 1094619-69-8 (R)-2,2,2-trifluoro-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 
• 1094619-88-1 (R)-6-(3-aminopyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 

Relevant articles and documents

THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS

The present invention is directed to novel thieno[2,3-d]pyrimidin-4(3H)-one, isoxazolo[5,4-d]pyrimidin-4(5H)-one and isothiazolo[5,4-d]pyrimidin-4(5H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula (I), wherein the variables R1, R2, R3, X and Z are as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.