200933-25-1

Usage

Uses

Used in Pharmaceutical Industry:
(METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is used as a building block for the synthesis of various drugs and organic compounds, contributing to the development of new pharmaceuticals.
Used in Chemical Reactions:
(METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is used as a reagent in chemical reactions, facilitating the creation of other organic molecules.
Used in Preparation of Other Organic Molecules:
(METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is used as a precursor for the preparation of other organic molecules, expanding its utility in the field of organic chemistry.
Safety Precautions:
Due to the presence of the nitro group in the molecule, (METHOXY)(3-NITROPYRIDIN-2-YL)METHANOL is potentially hazardous, and proper safety precautions should be taken when handling and storing it.

Upstream product

• 67-56-1 methanol 
• 150281-83-7 2-ethenyl-3-nitropyridine 
• 18699-87-1 2-methyl-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 1094619-87-0 (R)-6-(3-nitropyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 
• 1094619-88-1 (R)-6-(3-aminopyridin-2-yl)-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)isoxazolo[5,4-d]pyrimidin-4(5H)-one 
• 1094619-69-8 (R)-2,2,2-trifluoro-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 
• 1094619-66-5 (R)-N-(2-(4-oxo-5-(1-phenylpropan-2-yl)-3-(trifluoromethyl)-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)pyridin-3-yl)acetamide 

Relevant academic research and scientific papers

THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS

The present invention is directed to novel thieno[2,3-d]pyrimidin-4(3H)-one, isoxazolo[5,4-d]pyrimidin-4(5H)-one and isothiazolo[5,4-d]pyrimidin-4(5H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula (I), wherein the variables R1, R2, R3, X and Z are as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.

Efficient synthesis of ribonucleotide reductase inhibitors 3- aminopyridine-2-carboxaldehyde thiosemicorbazone (3-AP) and 3-amino-4- methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) via palladium mediated cross-coupling reactions

An efficient synthesis of potent ribonucleotide reductases inhibitors 3- amino-pyridine-2-carboxaldehyde thiosemicarbazone (3-AP) end 3-amino-4- methyl-pyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) is described. The synthesis of 3-AP and 3-AMP was achieved in 4 and 5 steps, with overall yields of 61% and 39%, respectively. The synthesis featured a convergent approach utilizing a Stille coupling strategy to prepare vinylpyridine derivatives. A more economic way to synthesize vinylpyridine using Heck reaction was also discussed.