200943-06-2

Upstream product

• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 7568-93-6 2-Amino-1-phenylethanol 

Downstream Products

• 200942-64-9 N-tert-butyloxycarbonyl-(6R)-3,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-on 
• 200943-08-4 [tert-Butoxycarbonyl-((R)-2-hydroxy-2-phenyl-ethyl)-amino]-phenyl-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of chiral α-substituted N-[((2S)-2-hydroxy-2-phenyl)-ethyl]-2-phenylglycine derivatives by diastereocontrolled alkylation of (6R)-2,3,5,6-tetrahydro-3,6-diaryl-N-[(2'R)-(2'-methyl)phenyl-methyl]-4H-1,4 -oxazin-2-ones

The synthesis of α-substituted N-[((2S)-2-hydroxy-2-phenyl)-ethyl]-2-phenylglycine derivatives is reported, The key step of the sequence is the highly diastereoselective alkylation of (6R)-2,3,5,6-tetrahydro-3,6-diaryl-N-[(2'R)-(2'-methyl)phenylmethyl]-4H-1,4 -oxazin-2-ones after deprotonation with t-BuOK. Opening of the resulting oxazinone with ethanolic KOH, followed by hydrogenolysis of the corresponding N-[(2R)-(2-methyl)phenylmethyl] compound to furnish the expected 2-phenylglycine derivative, is also described.