2882-19-1

Basic information

• Product Name: ETHYL ALPHA-BROMOPHENYLACETATE
• Synonyms: Phenylbromoacetic acid ethyl ester;α-Bromobenzeneacetic acid ethyl ester;α-Bromophenylacetic acid ethyl ester;Einecs 220-735-2;2-BroMo-2-phenylacetic Acid Ethyl Ester;DL-α-BroMophenylacetic Acid Ethyl Ester;Ethyl (±)-α-BroMobenzeneacetate;Bromo(phenyl)acetic acid ethyl ester, Ethyl 2-bromo-2-phenylethanoate
• CAS NO: 2882-19-1
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• EINECS: 220-735-2
• Product Categories: Pharmaceutical Intermediates;Esters;Phenyls & Phenyl-Het;C10 to C11;Carbonyl Compounds
• Mol File: 2882-19-1.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 89-92 °C0.9 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.389 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: n20/D >1.5390(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Not miscible or difficult to mix in water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: ETHYL ALPHA-BROMOPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL ALPHA-BROMOPHENYLACETATE(2882-19-1)
• EPA Substance Registry System: ETHYL ALPHA-BROMOPHENYLACETATE(2882-19-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2882-19-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2882-19-1 differently. You can refer to the following data:
1. ETHYL ALPHA-BROMOPHENYLACETATE is used as an alkyl halide initiator in controlled/living radical polymerization of styrene and methyl methacrylate.
2. α-Bromobenzeneacetic acid ethyl ester is used as an alkyl halide initiator in controlled/living radical polymerization of styrene and methyl methacrylate.

Application

Ethyl α-bromophenylacetate (EBPA) may be used to synthesize α-ethoxycarbonyl-N,α-diphenylnitrone.EBPA may be used as an initiator for the following:polymerization of dimethyl(methacryloyloxymethyl) phosphonatepolymerization of methyl methacrylate (MMA)polymerization of trimethylolpropane triacrylate(TMPTA)

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X

Precautions

Moisture sensitive. Store away from oxidizing agents, air and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas.

InChI:InChI=1/C10H11BrO2/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6H,2,7H2,1H3

Upstream product

• 103-82-2 phenylacetic acid 
• 59176-55-5 ethyl α,α-dibromobenzeneacetate 
• 78-94-4 methyl vinyl ketone 
• 75-15-0 carbon disulfide 
• 13049-42-8 phenylketene diethylacetal 
• 7726-95-6 bromine 
• 110-86-1 pyridine 
• 7789-60-8 phosphorus tribromide 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 91-22-5 quinoline 
• 121-69-7 N,N-dimethyl-aniline 
• 22065-57-2 ethyl 2-phenyldiazoacetate 
• 1133471-34-7 ethyl 2-bromo-2-(cyclohexa-2,5-dienyl)acetate 
• 16754-56-6 (2,2,2-triethoxyethyl)benzene 

Downstream Products

• 7550-06-3 ethyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 33973-14-7 6-methoxy-2-phenyl-1-benzofuran 
• 857798-18-6 phenyl-(3,1',3'-trioxo-2,3,1',3'-tetrahydro-[1,2']biindenyliden-2-yl)-acetic acid ethyl ester 
• 51580-78-0 2-(N-methyl-anilino)-5-phenyl-thiazol-4-one 
• 59378-14-2 (2-oxo-cyclohexyl)-phenyl-acetic acid ethyl ester 
• 4439-87-6 2-phenyllevulinic acid 
• 5634-59-3 Estere etilico dell'acido α-(4-clorofenilamino)-fenilacetico 
• 37563-27-2 ethyl 2-(ethylamino)-2-phenylacetate 
• 6319-70-6 ethyl α-N,N-dimethylphenyl acetate 
• 101450-09-3 (2-diethylamino-ethoxy)-phenyl-acetic acid ethyl ester 
• 67067-96-3 ethyl ester of N-benzyl-α-phenylglycine 
• 13638-89-6 meso-diethyl 2,3-diphenylsuccinate 
• 13584-18-4 (2-[1,3,4]oxadiazol-2-yl-phenoxy)-phenyl-acetic acid ethyl ester 
• 14618-72-5 <α-Ethoxycarbonyl-benzylmercapto>-essigsaeure-ethylester 

Relevant articles and documents

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

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Manganese-Catalyzed Dual-Deoxygenative Coupling of Primary Alcohols with 2-Arylethanols

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Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor

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