200957-26-2Relevant academic research and scientific papers
Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties
Dejmek, Milan,Hrebabecky, Hubert,Dracinsky, Martin,Neyts, Johan,Leyssen, Pieter,Mertlikova-Kaiserova, Helena,Nencka, Radim
experimental part, p. 1549 - 1566 (2012/05/05)
We report on the preparation of novel 1'-homonucleoside derivatives locked in a West conformation by 1',4'-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels-Alder reaction of an appropriate aryne with
Study of the pyrolytic chemistry of isobenzofurylmethyl benzoates
Chen, Ping-Shu,Chou, Chin-Hsing
, p. 17115 - 17126 (2007/10/03)
Pyrolysis of (1-isobenzofuryl)methyl benzoate (9a), produced in situ from flash vacuum pyrolysis of (7-oxa-1-benzonorbornenyl)methyl benzoate (10a), gave methylenebenzocyclobutenone (4), 2-ethynylbenzaldehyde (5) and benzocyclopentadienone (6). The deuterium-labeled study indicated that the mechanism for the formation of these products involved the double migrations of benzoate group in 9a. Pyrolysis of (3-methyl-1-isobenzofuryl)methyl benzoate (9c) gave 1,3-dimethylene-1,3-dihydroisobenzofuran (33), which is stable in benzene and hydrolyzed rapidly in chloroform to give 1,2-diacetylbenzene (35).
