20096-35-9Relevant academic research and scientific papers
Effect of a =X-NH-Fragment, (X = C, N), on Z/E Isomerization and ON/OFF Functionality of Isatin Arylhydrazones, ((Arylamino)Methylene)Indolin-2-Ones and Their Anions
?andrik, Róbert,Csicsai, Klaudia,Donovalová, Jana,Gáplovsky, Anton,Sokolík, Róbert,Tisovsky, Pavol
, (2020/07/25)
The subject of this work was the study of thermally and photochemically stimulated Z ? E isomerization and hydrazo ? azo tautomerism of Z- and E-isomers of isatin arylhydrazones and ((arylamino)methylene)indolin-2-ones and their anions. Using NMR, UV-Vis spectroscopy, kinetic measurements, and HPLC, we studied the relationship of structure, (Z- and E-isomers), of these compounds and hydrazo=azo tautomerism. The ON/OFF functionality of these compounds and their anions using light to stimulate switching between ON and OFF states was investigated. We pointed out the characterization of the effect of =N- and =CH- structural fragments and aryl structure on ON and OFF states of isatin arylhydrazones and ((arylamino)methylene)indolin-2-ones.
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds
Lawrence, Harshani R.,Pireddu, Roberta,Chen, Liwei,Luo, Yunting,Sung, Shen-Shu,Szymanski, Ann Marie,Yip, M. L. Richard,Guida, Wayne C.,Sebti, Sa?d M.,Wu, Jie,Lawrence, Nicholas J.
experimental part, p. 4948 - 4956 (2009/07/11)
Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 μM. A focused library incorporating an isatin scaffold was designed a
INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-87877, NSC-117199 AND THEIR ANALOGS
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Page/Page column 39, (2010/11/28)
Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and NSC-117199 have been identified as Shp2 PTP inhibitors. Signif
Hydrazone derivatives and their use
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, (2008/06/13)
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-h
