20099-25-6Relevant academic research and scientific papers
Design, synthesis, and pharmacological investigation of iodined salicylimines, new prototypes of antimicrobial drug candidates
Xu, Suo-Ping,Lv, Peng-Cheng,Shi, Lei,Zhu, Hai-Liang
experimental part, p. 282 - 290 (2011/07/08)
A series of 3,5-diiodo-salicylalidene Schiff bases (compounds 1 - 35) has been synthesized and tested for antimicrobial activity. The compounds were assayed for antibacterial activities by the MTT method. Some of the compounds inhibit the growth of a broad range of bacteria including the species of Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae. Among them, compounds 2-[(4-chloro-phenylimino)-methyl]-4,6-diiodo-phenol 11 and 2,4-diiodo-6-[(2- morpholin-4-yl-ethylimino)methyl]phenol 19 showed the most potent antibacterial activity with MIC of 3.1, 12.9, 3.3, 6.5, 12.9, 3.3 and 3.2, 12.8, 3.2, 12.8, 12.8, 3.2 μM against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. Coli, and E. cloacae, respectively.
