201050-01-3Relevant academic research and scientific papers
Intramolecular nucleophilic attack at silicon in o-silylbenzyl alcohols. Generation of allyl and benzyl anion equivalents
Hudrlik, Paul F.,Hudrlik, Anne M.,Jeilani, Yassin A.
, p. 10089 - 10096 (2012/02/13)
Substituted silyl ethers of o-bromobenzyl alcohols and the derived o-silylbenzyl alcohols were used to transfer allyl and benzyl groups from silicon to the electrophiles benzaldehyde and benzophenone in excellent yields. γ-Oxidosilane intermediates (and possibly hypercoordinated silicon intermediates) are postulated.
Silicon-Based Cross-Coupling Reagent and Production Method of Organic Compound Using the Same
-
Page/Page column 14, (2009/04/24)
In one embodiment of the present invention, a silicon-based cross-coupling reagent is disclosed which is a highly stable tetraorganosilicon compound allowing for a cross-coupling reaction under mild reaction conditions without using fluoride ions, transition metal promoter, or strong bases, and the residue of the silicon reagent can be recovered and reused. The silicon-based cross-coupling reagent is a silicon compound in which an o-hydroxymethylphenyl group is connected to a silicon atom for intramolecular activation.
