80735-94-0

Basic information

• Product Name: 1-PHENYL-3-BUTEN-1-OL
• Synonyms: phenylbutenol;4-PHENYL-1-BUTEN-4-OL;1-PHENYL-3-BUTENE-1-OL;1-PHENYL-3-BUTEN-1-OL
• CAS NO: 80735-94-0
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• Mol File: 80735-94-0.mol
• Article Data: 638

Chemical Properties

• Boiling Point: 234 °C(lit.)
• Flash Point: 217 °F
• Appearance: /
• Density: 0.992 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.53(lit.)
• CAS DataBase Reference: 1-PHENYL-3-BUTEN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-3-BUTEN-1-OL(80735-94-0)
• EPA Substance Registry System: 1-PHENYL-3-BUTEN-1-OL(80735-94-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 2
• Hazardous Substances Data: 80735-94-0(Hazardous Substances Data)

Usage

Uses

4-Phenyl-1-buten-4-ol is a building block that can be used in the synthesis of (R)-2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one (H447850), which is an impurity of Propafenone (P757500), a sodium channel blocker and an antiarrhythmic (class IC) compound.

Upstream product

• 100-52-7 benzaldehyde 
• 106-95-6 allyl bromide 
• 1730-25-2 allylmagnesium bromide 
• 17364-45-3 (±)-(1R*,2R*)-(2-phenylcyclopropyl)methyl acetate 
• 98-86-2 acetophenone 
• 13360-20-8 (allyloxy)dimethylphenylsilane 
• 627-15-6 1,3-dibromopropene 
• 1793-91-5 tetraallylgermanium 
• 1793-90-4 allyltriethylgermane 
• 23253-30-7 3-Phenyl-1,2,4-trioxolane 
• 762-72-1 allyl-trimethyl-silane 
• 249894-61-9 3-Phenyl-1,2,4-trioxaspiro[5.4]decane 
• 249894-62-0 3-Phenyl-5-propyl-1,2,4-trioxolane 
• 50-00-0 formaldehyd 

Downstream Products

• 71052-93-2 1-phenyl-1,4-dibromobutane 
• 943621-73-6 4-phenylbutane-1,2,4-triol 
• 132587-07-6 1-phenylbut-3-enyl acetate 
• 70241-16-6 4-tert-Butylphosphanyl-1-phenyl-butan-1-ol 
• 65760-64-7 4-(tert.-Butylamino)-1-phenyl-1,3-butandiol 
• 62296-25-7 4-(1,1-dimethylethylthio)-1-phenyl-1-butanol 
• 1026576-66-8 C₁₁H₁₁ClO₂ 
• 130279-54-8 diethyl 1-phenylbut-3-enyl phosphite 
• 80696-76-0 N-(1-phenylbut-3-en-1-yl)glutarimide 
• 73157-68-3 6-hydroxy-(1-phenylbut-3-en-1-yl)-2-piperidinone 
• 134370-26-6 2-(3-Methyl-4,5-dihydro-isoxazol-5-yl)-1-phenyl-ethanol 
• 133699-08-8 C₁₅H₂₆OSi₂ 
• 53847-13-5 3-hydroxy-3-phenylhexa-1,5-diene 
• 122293-92-9 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-phenyl-but-3-enyl ester 

Relevant articles and documents

The Mechanism of the Palladium-catalysed Reaction of Allylic Acetates with Carbonyl Compounds via Electrochemical Reduction

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Synthesis of a new C2-symmetric chirat diol: Application to asymmetric allylboration.

New C2-symmetric chiral diol 1b was prepared from diol 3a, by a thionyl chloride mediated double elimination, hydrogenation and deprotection sequence. A comparative study of the asymmetric allylboration of benzaldehyde with the allylboronates 1

Simultaneous coordination and double activation phenomena of carbonyl and epoxy oxygen by bis-titanium reagent as a bidentate lewis acid catalyst

The new bidentate Ti catalyst, (anthraquinone-1,8- dioxy)bis(triisopropoxy-titanium) (1) can be successfully designed and utilized for the simultaneous coordination to carbonyl substrates. The high double-activation ability of the bidentate Ti catalyst 1 toward carbonyls is emphasized using several synthetic examples in comparison with the corresponding monodentate Ti catalyst. The intermediary coordination complex formation of bidentate 1 with DMF or epoxycyclohexane as a carbonyl or epoxy substrate is characterized by 13C NMR spectroscopy.

Isostructural mesoporous ionic crystals as a tunable platform for acid catalysis

Eleven isostructural mesoporous ionic crystals (meso-PICs) are synthesized. The initial activities of the Barbier-Grignard reaction, which is a typical C-C bond formation reaction, catalyzed by the meso-PICs are dependent on the acid dissociation constant

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The impact of the structure and conformation of formamides as organocatalysts was investigated and reported herein as a structure-activity relationship. Selected formamides and some amides were evaluated for their ability to activate allyltrichlorosilane

Indium-mediated allylation of carbonyl compounds in deep eutectic solvents

This study describes, for the first time, the in situ generation of indium organometallic reagents in environmentally friendly deep eutectic solvents (DESs). The allylation process of different carbonyl compounds is achieved mediated by indium metal and u

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Palladium-catalyzed remote arylative substitution was achieved for the reaction of arylboronic acids with alkenes possessing a distant acetoxy group to provide arylation products having an alkene moiety at the remote position. The use of β-acetoxy elimination as a key step in the catalytic cycle allowed for regioselective formation of unstabilized alkenes after chain walking. This reaction was applicable to various arylboronic acids as well as alkene substrates.