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1-PHENYL-3-BUTEN-1-OL, also known as 4-Phenyl-1-buten-4-ol, is an organic compound that serves as a valuable building block in the synthesis of various pharmaceutical compounds.
Used in Pharmaceutical Industry:
1-PHENYL-3-BUTEN-1-OL is used as a synthetic building block for the production of (R)-2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one (H447850), which is an impurity of Propafenone (P757500). Propafenone is a sodium channel blocker and an antiarrhythmic (class IC) compound, utilized in the treatment of cardiac arrhythmias. The synthesis of 1-PHENYL-3-BUTEN-1-OL plays a crucial role in ensuring the purity and efficacy of Propafenone as a medication.

80735-94-0

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80735-94-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80735-94-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,3 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 80735-94:
(7*8)+(6*0)+(5*7)+(4*3)+(3*5)+(2*9)+(1*4)=140
140 % 10 = 0
So 80735-94-0 is a valid CAS Registry Number.

80735-94-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-PHENYL-3-BUTEN-1-OL

1.2 Other means of identification

Product number -
Other names (d,l)-1-Hydroxy-1-phenyl-3-butene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80735-94-0 SDS

80735-94-0Relevant academic research and scientific papers

The Mechanism of the Palladium-catalysed Reaction of Allylic Acetates with Carbonyl Compounds via Electrochemical Reduction

Zhang, Pingping,Zhang, Wuchang,Zhang, Tingfang,Wang, Zhiqin,Zhou, Wenjuan

, p. 491 - 492 (1991)

The mechanism of Pd-catalysed reaction of allylic acetates with carbonyl compounds in the presence of zinc chloride via electroreduction is reported.

New computational and experimental evidence for the mechanism of the Sakurai reaction

Bottoni, Andrea,Costa, Anna Luisa,Di Tommaso, Donata,Rossi, Ivan,Tagliavini, Emilio

, p. 12131 - 12135 (1997)

Reaction of aldehydes with allyltrimethylsilane promoted by BF3 (Sakurai reaction) affords fluorotrimethylsilane and a borylated homoallylic alcohol in a noncatalytic fashion. These reaction products have been identified through 13C

Synthesis of 4-aminotetrahydropyran scaffolds for drug discovery

Nortcliffe, Andrew,Milne, Gavin D.S.,Hamza, Daniel,Moody, Christopher J.

, p. 2218 - 2225 (2017)

Functionalised tetrahydropyran scaffolds were prepared using a tethered enol-ether Prins cyclisation and elaborated to show their potential use in library synthesis. The key 4-hydroxytetrahydropyran scaffold could be readily manipulated to the 4-azidotetr

Preparation of active zinc by reduction of zinc chloride with sodium in liquid ammonia and its use in the Barbier reaction

Makosza, Mieczysaw,Grela, Karol

, p. 9225 - 9226 (1995)

Active zinc powder produced by reduction of anhydrous zinc chloride with solution of sodium in liquid ammonia exhibits high reactivity in the Barbier type reaction both in THF and liquid ammonia solution.

Synthesis of a new C2-symmetric chirat diol: Application to asymmetric allylboration.

Mears, Richard J.,De Silva, Harshani,Whiting, Andrew

, p. 17395 - 17406 (1997)

New C2-symmetric chiral diol 1b was prepared from diol 3a, by a thionyl chloride mediated double elimination, hydrogenation and deprotection sequence. A comparative study of the asymmetric allylboration of benzaldehyde with the allylboronates 1

Reaction Pathway and Transition State of the Zn-Promoted Barbier-Type Reactions of Benzaldehyde and Benzophenone with Allylic Iodides

Yamataka, Hiroshi,Nishikawa, Kazuyoshi,Hanafusa, Terukiyo

, p. 242 - 245 (1994)

The carbonyl-14C kinetic isotope effects and the substituent effects on the reactivity of the Zn-promoted Barbier-type reaction of allyl iodide (3-iodo-1-propene) with benzaldehyde and benzophenone were determined in THF at 25 deg C.The observed normal ca

Simultaneous coordination and double activation phenomena of carbonyl and epoxy oxygen by bis-titanium reagent as a bidentate lewis acid catalyst

Asao, Naoki,Kii, Satoshi,Hanawa, Hideo,Maruoka, Keiji

, p. 3729 - 3732 (1998)

The new bidentate Ti catalyst, (anthraquinone-1,8- dioxy)bis(triisopropoxy-titanium) (1) can be successfully designed and utilized for the simultaneous coordination to carbonyl substrates. The high double-activation ability of the bidentate Ti catalyst 1 toward carbonyls is emphasized using several synthetic examples in comparison with the corresponding monodentate Ti catalyst. The intermediary coordination complex formation of bidentate 1 with DMF or epoxycyclohexane as a carbonyl or epoxy substrate is characterized by 13C NMR spectroscopy.

Chemoselective RuO4 oxidation of phenyl or p-methoxyphenyl groups to carboxylic acid functions in the presence of a tetrahydropyran ring

Miranda,Vasconcellos

, p. 1767 - 1770 (2004)

We describe the first example of a chemoselective oxidation of phenyl and p-methoxyphenyl groups to carboxylic acid functions in the presence of a tetrahydropyran ring, using 0.02 mol% of RuCl3 and a co-oxidant. The use of NaIO4 as c

Isostructural mesoporous ionic crystals as a tunable platform for acid catalysis

Kikukawa, Yuji,Kitao, Takashi,Ogiwara, Naoki,Shimoyama, Yuto,Uchida, Sayaka,Weng, Zhewei

, p. 10328 - 10333 (2020)

Eleven isostructural mesoporous ionic crystals (meso-PICs) are synthesized. The initial activities of the Barbier-Grignard reaction, which is a typical C-C bond formation reaction, catalyzed by the meso-PICs are dependent on the acid dissociation constant

Structure-activity relationship of formamides as organocatalysts: The significance of formamide structure and conformation

Nguyen, Dieu,Akhani, Ravish K.,Sheppard, Cody I.,Wiskur, Sheryl L.

, p. 2279 - 2283 (2013)

The impact of the structure and conformation of formamides as organocatalysts was investigated and reported herein as a structure-activity relationship. Selected formamides and some amides were evaluated for their ability to activate allyltrichlorosilane

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