2011-09-8Relevant articles and documents
Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists
Allison, Brett D.,Phuong, Victor K.,McAtee, Laura C.,Rosen, Mark,Morton, Magda,Prendergas, Clodagh,Barrett, Terry,Lagaud, Guy,Freedman, Jamie,Li, Na,Wu, Xiaodong,Venkatesan, Hariharan,Pippel, Marna,Woods, Craig,Rizzolio, Michèle C.,Hack, Michael,Hoey, Kenway,Deng, Xiaohu,King, Christopher,Shankley, Nigel P.,Rabinowitz, Michael H.
, p. 6371 - 6390 (2008/04/18)
A high throughput screening approach to the identification of selective cholecystokinin-2 receptor (CCK-2R) ligands resulted in the discovery of a novel series of antagonists, represented by 1-[2-[(2,1,3-benzothiadiazol-4- ylsulfonyl)amino]-5-chlorobenzoy
Process for the preparation of fluorinated benzoic acids
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, (2008/06/13)
A process for the preparation of 2-chloro-4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid as well as synthetic intermediates useful in and prepared according thereto, comprising reacting a nitrobenzene having the formula STR1 wherein X is chloro or fluoro, with an appropriate carbanion to form a compound having the formula STR2 wherein one of Y and Z is chloro and the other is nitro, and R is a radical selected from the group consisting of --CCl3, --CH2 NO2, --CH(NO2)R1, --CH(CO2 R1)2, --CH(C(O)R2)2, --CH(CN)CO2 R1, --CH(CO2 R1)COR2 and --COR2 where R1 is alkyl or arylalkyl and R2 is alkyl, aryl or arylalkyl and, where appearing more than once in such a radical, R1 and R2 may be the same or different at each occurrence.
