2011-70-3

Basic information

• Product Name: N-(2-benzoyl-4-nitrophenyl)-2-bromoacetamide
• Synonyms: N-(2-benzoyl-4-nitrophenyl)-2-bromoacetamide;EINECS 217-932-0;2-(2-Bromoacetamido)-5-nitrobenzophenone;2'-Benzoyl-2-bromo-4'-nitroacetanilide;5-Nitro-2-(bromoacetamido)benzophenone
• CAS NO: 2011-70-3
• Molecular Formula: C₁₅H₁₁BrN₂O₄
• Molecular Weight: 363.16284
• EINECS: 217-932-0
• Product Categories: Aromatics;Neurochemicals
• Mol File: 2011-70-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 156-158°C
• Boiling Point: 590.3 °C at 760 mmHg
• Flash Point: 310.8 °C
• Appearance: /
• Density: 1.609 g/cm³
• Vapor Pressure: 6.55E-14mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
• CAS DataBase Reference: N-(2-benzoyl-4-nitrophenyl)-2-bromoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzoyl-4-nitrophenyl)-2-bromoacetamide(2011-70-3)
• EPA Substance Registry System: N-(2-benzoyl-4-nitrophenyl)-2-bromoacetamide(2011-70-3)

Safety Data

• Hazardous Substances Data: 2011-70-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Solid

Uses

Different sources of media describe the Uses of 2011-70-3 differently. You can refer to the following data:
1. Nitrazepam derivative
2. Nitrazepam derivative.

InChI:InChI=1/C15H11BrN2O4/c16-9-14(19)17-13-7-6-11(18(21)22)8-12(13)15(20)10-4-2-1-3-5-10/h1-8H,9H2,(H,17,19)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 98-88-4 benzoyl chloride 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 24143-26-8 10-nitro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 
• 24111-60-2 N-(2-hydroxy-propyl)-glycine 2-benzoyl-4-nitro-anilide 
• 2011-69-0 2-amino-N-(2-benzoyl-4-nitrophenyl)acetamide 
• 29711-54-4 3-methyl-10-nitro-11b-phenyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 32822-88-1 7-ethyl-10-nitro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 
• 32711-31-2 7-methyl-10-nitro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 

Relevant articles and documents

Effect of substituents on the configurational stability of the stereogenic nitrogen in metal(II) complexes of α-amino acid Schiff bases

Herein, we report a general method for quantitative measurement of the configurational stability of the stereogenic nitrogen coordinated to M (II) in the corresponding square planar complexes. This stereochemical approach is quite sensitive to steric and electronic effects of the substituents and shown to work well for Ni(II), Pd(II), and Cu(II) complexes. Structural simplicity of the compounds used, coupled with high sensitivity and reliability of experimental procedures, bodes well for application of this approach in evaluation of chemical stability and stereochemical properties of newly designed chiral ligands for general asymmetric synthesis of tailor-made amino acids.

Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties

We synthesized 3-O-methylviridicatin 1 and several analogues of this fungal metabolite. We showed that replacement of the methoxy moiety by a thiomethyl enhanced dramatically its ability to inhibit TNF-α secretion. These results strongly suggest that 4-phenyl-3-methylthioquinolinone 3 may provide the basis for the development of new anti-inflammatory agents.