201136-68-7

Upstream product

• 70113-32-5 [(S)-2-methoxymethylpyrrolidin-1-yl]-N-propylideneamine 
• 201136-67-6 4-[(1E,5E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-9-iodo-2-methyl-6-trityloxymethyl-nona-1,5-dienyl]-2-methyl-thiazole 
• 76-83-5 trityl chloride 
• 193146-41-7 (2E,6E)(5S)-6-methyl-7-(2-methyl-(1,3-thiazol-4-yl))-2-prop-2-enyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hepta-2,6-dien-1-ol 
• 201136-65-4 4-[(1E,5E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-6-trityloxymethyl-nona-1,5,8-trienyl]-2-methyl-thiazole 
• 201136-66-5 (4E,8E)-(S)-7-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-9-(2-methyl-thiazol-4-yl)-4-trityloxymethyl-nona-4,8-dien-1-ol 

Downstream Products

• 201136-71-2 (12E,16E)-(3S,6R,7S,8S,15S)-1,3,15-Tris-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 201136-73-4 (12E,16E)-(3S,6R,7S,8S,15S)-1,3,7,15-Tetrakis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 201136-74-5 (12E,16E)-(3S,6R,7S,8S,15S)-3,7,15-Tris-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-12-trityloxymethyl-heptadeca-12,16-dien-5-one 
• 201136-70-1 (6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,10-dimethyl-11-(2-methyl-thiazol-4-yl)-6-trityloxymethyl-undeca-6,10-dienal 
• 201136-69-8 (6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,10-dimethyl-11-(2-methyl-thiazol-4-yl)-6-trityloxymethyl-undeca-6,10-dienenitrile 

Relevant academic research and scientific papers

Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy

The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxy-epothilone B (7), prepared via the macrolactonization strategy, served as a common precursor to the designed epothilones described. The synthesized compounds were members of a large epothilone library whose biological screening led to the identification of a number of highly potent antitumor agents.