70113-32-5

Basic information

• Product Name: 1-Pyrrolidinamine, 2-(methoxymethyl)-N-propylidene-, (2S)-
• CAS NO: 70113-32-5
• Molecular Formula: C9H18N2O
• Molecular Weight: 170.255
• Mol File: 70113-32-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinamine, 2-(methoxymethyl)-N-propylidene-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinamine, 2-(methoxymethyl)-N-propylidene-, (2S)-(70113-32-5)
• EPA Substance Registry System: 1-Pyrrolidinamine, 2-(methoxymethyl)-N-propylidene-, (2S)-(70113-32-5)

Safety Data

• Hazardous Substances Data: 70113-32-5(Hazardous Substances Data)

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 123-38-6 propionaldehyde 

Downstream Products

• 193146-31-5 [(S)-6-Benzyloxy-2-methyl-hex-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 201136-68-7 [(6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,10-dimethyl-11-(2-methyl-thiazol-4-yl)-6-trityloxymethyl-undeca-6,10-dien-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 870192-60-2 (S)-2-Methyl-hexadecanal 
• 1194510-08-1 N-[(S)-3-(3,4-dimethoxyphenyl)-2-methylpropylidene]-[(S)-2-methoxymethylpyrrolidin-1-yl]amine 
• 611168-49-1 [(S)-5-((1S,2R)-2-Benzyloxymethyl-1-methyl-cyclopropyl)-2-methyl-pent-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 240815-94-5 [(6E,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-iodo-2,10-dimethyl-6-trityloxymethyl-undeca-6,10-dien-(E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 

Relevant articles and documents

Asymmetric synthesis of α-(heteroaryl)alkylamines and α-amino acids via nucleophilic 1,2-addition of lithiated heterocycles to aldehyde SAMP-hydrazones

The asymmetric synthesis of α-(heteroaryl)alkylamines was accomplished by employing a diastereoselective nucleophilic 1,2-addition of lithiated aromatic heterocycles to aldehyde SAMP-hydrazones, followed by BH 3·THF or SmI2 promoted removal of the chiral auxiliary. The CBz or benzoyl-protected amines were obtained in good yields (40%-78%) and excellent enantiomeric excesses (ee = 88%-99%). The methodology can be applied to the synthesis of highly enantioenriched α-amino acids (ee = 90%-99%). TUeBITAK.

Asymmetric synthesis of 3- or 4-alkyl or arylbenzo[c]azepines

Two flexible routes for the stereoselective synthesis of a variety of 3- or 4-alkylated or arylated tetrahydrobenzazepines have been developed. The key steps are the highly diastereoselective metallation/alkylation reaction and 1,2-addition processes applied to stereopure SAMP hydrazones combined with a cyclomethylenation reaction.

ASYMMETRIC MICHAEL ADDITIONS VIA SAMP-/RAMP-HYDRAZONES ANTI-DIASTEREO- AND ENANTIOSELECTIVE SYNTHESIS OF 3,4-DISUBSTITUTED 5-OXO-ALKANOATES

An efficient and highly anti-diastereo-(de=90-100percent) and enantioselective (ee=92-100percent) synthesis of 3,4-disubstituted 5-oxo-alkanoates 3 in good overall chemical yields is described.The procedure involves the asymmetric Michael addition of aldehydes or ketones to enoates via their lithiated SAMP-/RAMP-hydrazones.Both enantiomers are accessible at will.