201142-75-8

Usage

Uses

Used in Pharmaceutical Industry:
(E)-3-(2-Methylthiazol-4-yl)acrylic acid is used as an intermediate in the synthesis of various organic compounds for the development of pharmaceutical products. Its unique structure and reactivity contribute to the creation of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-3-(2-Methylthiazol-4-yl)acrylic acid serves as a building block for the synthesis of compounds with pesticidal or herbicidal properties. Its chemical properties allow for the development of effective and targeted agrochemicals.
Used in Research and Development:
(E)-3-(2-Methylthiazol-4-yl)acrylic acid is utilized in research and development contexts to study chemical reactions and develop new materials. Its versatility and reactivity make it a valuable compound for exploring novel chemical pathways and creating innovative products.

Upstream product

• 216318-31-9 (2E)-3-(2-Methylthiazol-4-yl)-2-propenoic acid methyl ester 
• 20949-84-2 2-methylthiazole-4-carbaldehyde 
• 141-82-2 malonic acid 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1 -associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictyin libraries

Isolated from certain species of soft corals, the sarcodictyins, eleutherobin, and eleuthosides have become important synthetic targets due the their novel molecular architectures, important biological activities, and potential in medicine. Of particular interest is their Taxol-like mechanism of action involving disturbance of the tubulin-microtubule interplay resulting in tumor cell death. Their scarcity and biological profile prompted us to initiate a program directed at exploring their chemical synthesis and chemical biology. Herein we report (a) the first total synthesis of sarcodictyins A (7) and B (8) by a combination of solution and solid-phase methods through the attachment of the common precursors 18 or 20 on solid support, thus generating conjugates 23 and 24, followed by standard chemical manipulations; (b) the construction of a combinatorial library of sarcodictyins by solution and solid-phase chemistry modifying the C-8 ester, C-15 ester, and C-4 ketal functionalities, and, therefore, producing analogues of the general structures 33, 37, and 40; (c) the tubulin polymerization properties of all members of the library; and (d) the cytotoxic actions of a selected number of these compounds against a number of tumor cells including Taxol-resistant lines. Several of the synthesized analogues were identified to be of equal or superior biological activities (e.g. 60, 61, 63, 66-70, 73, 76, 85, 92) as compared to the natural products, setting the stage for further developments in the field of cancer chemotherapy.