20115-17-7

Usage

Chemical structure

A cyclohexanone derivative with two dimethylamino methyl groups attached to the 2 and 6 positions of the cyclohexanone ring.

Common uses

用作各种制药的前体、有机合成中的试剂、农用化学品和其他特殊化学品生产中的关键中间体。
受欢迎程度：在研究界因其多功能性和潜在的药物发现和开发应用而备受推崇。

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 108-94-1 cyclohexanone 
• 124-40-3 dimethyl amine 

Downstream Products

• 100392-29-8 2,6-Bis-dimethylaminomethyl-cyclohexanol 
• 114159-70-5 diphenyl-acetic acid-(2,6-bis-dimethylaminomethyl-cyclohexyl ester) 

Relevant academic research and scientific papers

Evaluation of net antioxidant activity of mono- and bis-Mannich base hydrochlorides and 3-keto-1,5-bisphosphonates from their ProAntidex parameter

Abstract A series of mono- and bis-Mannich base hydrochlorides and of 3-keto-1,5-bisphosphonates were prepared and characterized on the basis of their infrared (IR), 1H, 13C and 31P NMR spectral data. All the title compounds were tested for their in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), H2O2, hydroxyl radical and Ferric Reducing Power (FRP) methods. The antioxidant activity of these compounds was analyzed simultaneously with their pro-oxidant capacity. The ratio of pro-oxidant to the antioxidant activity (ProAntidex) represents a useful index of the net free radical scavenging potential of the synthesized compounds. Ferrous, calcium and magnesium ion chelating abilities were also evaluated. All the tested compounds showed significant antioxidant activity and high ProAntidex.

5-NORBORNENE-2-SPIRO-a-CYCLOALKANONE-a'-SPIRO-2''-5''-NORBORNENE AND METHOD FOR PRODUCING THE SAME

A 5-norbornene-2-spiro-α-cycloalkanone-α′-spiro-2″-5″-norbornene represented by the following general formula (1): [in the formula (1), R1s, R2, and R3 each independently represent a hydrogen atom or the like, and n represents an integer of 0 to 12].

NORBORNANE-2-SPIRO- A-CYCLOALKANONE-A '-SPIRO-2''-NORBORNANE-5,5'',6,6''-TETRACARBOXYLIC DIANHYDRIDE, NORBORNANE-2-SPIRO- A-CYCLOALKANONE-A '-SPIRO-2''-NORBORNANE-5,5'',6,6''-TETRACARBOXYLIC ACID AND ESTER THEREOF, METHOD FOR PRODUCING NORBORNANE-2-SPIRO-

A norbornane-2-spiro-α-cycloalkanone-α'-spiro-2"-norbor nane-5,5",6,6"-tetracarboxylic dianhydride represented by the following general formula (1): [in the formula (1), n represents an integer of 0 to 12, and R1s, R2, R3

Evaluation of some Mannich bases of cycloalkanones and related compounds for cytotoxic activity

A number of Mannich bases of cycloalkanones and related quaternary ammonium compounds were prepared for cytotoxic evaluation in order to examine the theory that sequential release of alkylating agents produces increased bioactivity compared to related compounds containing only 1 potential alkylating site.Many of the compounds had significant activity against murine L1210 cells and various human tumours.Some correlations between structure and activity were noted but the biological data did not support the view that potential sequential liberation of cytotoxic species produced compounds with increased potency.The formation of various oximes and oxime benzoates as candidate prodrugs was achieved but in general these compounds were not cytotoxic at the concentrations utilized.This observation may be due to the fact that the oximes were much more stable in deuterated phosphate buffered saline over a period of 48 h at 37 deg than the Mannich bases, as revealed by 1H-NMR spectroscopy. Mannich bases / cytotoxic evaluations / prodrugs / 1H-NMR spectroscopy / structure-activity relationships